Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

Traumatic brain injury (TBI) leads to increased rates of dementia, including Alzheimer's
disease. The mechanisms by which trauma can trigger neurodegeneration are increasingly …

Cognitive dysfunction and reactive microglia are hallmarks of traumatic brain injury (TBI), yet
whether these cells contribute to cognitive deficits and secondary inflammatory pathology …

Axonal injury is a key determinant of long-term outcomes after traumatic brain injury (TBI) but
has been difficult to measure clinically. Fluid biomarker assays can now sensitively quantify …

A growing need exists for reliable in-vivo measurement of neuroinflammation to better
characterise the inflammatory processes underlying various diseases and to inform the …

Traumatic spinal cord injury is a devastating insult followed by progressive cord atrophy and
neurodegeneration. Dysregulated or non-resolving inflammatory processes can disturb …

Traumatic brain injury is associated with elevated rates of neurodegenerative diseases such
as Alzheimer's disease and chronic traumatic encephalopathy. In experimental models …

Occupational injuries and toxicant exposures lead to the development of neuroinflammation
by activating distinct mechanistic signaling cascades that ultimately culminate in the …

Chemotherapy is a life‐saving treatment for cancer patients, but also causes long‐term
cognitive impairment, or “chemobrain”, in survivors. However, several challenges, including …

Microglia, brain resident immune cells, modulate development, activity, and plasticity of the
central nervous system. Mechanistically implicated in numerous neurological pathologies …