The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …

Frailty is a multiply determined, age-related state of increased risk for adverse health
outcomes. We review how the degree of frailty conditions the development of late-life …

Animal studies show aging varies between individuals as well as between organs within an
individual,,–, but whether this is true in humans and its effect on age-related diseases is …

Recent understanding of how the systemic environment shapes the brain throughout life has
led to numerous intervention strategies to slow brain ageing,–. Cerebrospinal fluid (CSF) …

The circulating proteome offers insights into the biological pathways that underlie disease.
Here, we test relationships between 1,468 Olink protein levels and the incidence of 23 age …

The study of proteins circulating in blood offers tremendous opportunities to diagnose,
stratify, or possibly prevent diseases. With recent technological advances and the urgent …

Mechanisms governing the maintenance of blood-producing hematopoietic stem and
multipotent progenitor cells (HSPCs) are incompletely understood, particularly those …

Simple Summary Many modalities used to treat or control cancer lead to accelerated aging
in cancer survivors. However, the effects of cancer treatments on aging in individuals with …

Beyond mere prognostication, optimal biomarkers of aging provide insights into qualitative
and quantitative features of biological aging and might, therefore, offer useful information for …

Diverse individuals age at different rates and display variable susceptibilities to tissue aging,
functional decline and aging-related diseases. Centenarians, exemplifying extreme …