Great progress has been made over the past half-century, but TB remains a formidable
global health problem, particularly in low-and middle-income countries. Understanding the …

The clinical use of antibiotics has led to the emergence of multidrug-resistant (MDR)
bacteria, leading to the current antibiotic resistance crisis. To address this issue, next …

Summary Bacille Calmette-Guerin (BCG), the only approved Mycobacterium tuberculosis
(Mtb) vaccine, provides limited durable protection when administered intradermally …

Correlates of protection are key for vaccine development against any pathogen. In this paper
we summarize recent information about correlates for vaccines against dengue, Ebola …

Background An estimated one fourth of the world's population is infected with
Mycobacterium tuberculosis, and 5–10% of those infected develop tuberculosis in their …

Tuberculosis has affected humankind for thousands of years, but a deeper understanding of
its cause and transmission only arose after Robert Koch discovered Mycobacterium …

Background Tuberculosis is a preventable disease. However, there is debate regarding
which individuals would benefit most from tuberculosis preventive treatment and whether …

Trained immunity is a long-term memory of innate immune cells, generating an improved
response upon reinfection. Shigella is an important human pathogen and inflammatory …

Blood-based correlates of vaccine-induced protection against tuberculosis (TB) are urgently
needed. Here, we analyze the blood transcriptome of rhesus macaques immunized with …

The development of preventive and therapeutic vaccines has played a crucial role in
preventing infections and treating chronic and non-communicable diseases, respectively …