Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor
The discovery of robust antidepressant actions exerted by the N-methyl-D-aspartate receptor
(NMDAR) antagonist (R, S)-ketamine has been a crucial breakthrough in mood disorder …
(NMDAR) antagonist (R, S)-ketamine has been a crucial breakthrough in mood disorder …
The mechanisms behind rapid antidepressant effects of ketamine: a systematic review with a focus on molecular neuroplasticity
The mechanism of action underlying ketamine's rapid antidepressant effects in patients with
depression, both suffering from major depressive disorder (MDD) and bipolar disorder (BD) …
depression, both suffering from major depressive disorder (MDD) and bipolar disorder (BD) …
Psychedelics and neural plasticity: therapeutic implications
Psychedelic drugs have reemerged as tools to treat several brain disorders. Cultural
attitudes toward them are changing, and scientists are once again investigating the neural …
attitudes toward them are changing, and scientists are once again investigating the neural …
Single-cell epigenome analysis reveals age-associated decay of heterochromatin domains in excitatory neurons in the mouse brain
Loss of heterochromatin has been implicated as a cause of pre-mature aging and age-
associated decline in organ functions in mammals; however, the specific cell types and gene …
associated decline in organ functions in mammals; however, the specific cell types and gene …
Anatomical and molecular characterization of parvalbumin-cholecystokinin co-expressing inhibitory interneurons: implications for neuropsychiatric conditions
Inhibitory interneurons are crucial to brain function and their dysfunction is implicated in
neuropsychiatric conditions. Emerging evidence indicates that cholecystokinin (CCK) …
neuropsychiatric conditions. Emerging evidence indicates that cholecystokinin (CCK) …
NMDA receptors regulate the firing rate set point of hippocampal circuits without altering single-cell dynamics
A Ruggiero, LR Heim, L Susman, D Hreaky, I Shapira… - Neuron, 2025 - cell.com
Understanding how neuronal circuits stabilize their activity is a fundamental yet poorly
understood aspect of neuroscience. Here, we show that hippocampal network properties …
understood aspect of neuroscience. Here, we show that hippocampal network properties …
Dysfunction of NRG1/ErbB4 signaling in the Hippocampus might mediate long-term memory decline after systemic inflammation
Y Gao, X Wu, Z Zhou, P Liu, J Yang, M Ji - Molecular Neurobiology, 2023 - Springer
Accumulating evidence has suggested that a great proportion of sepsis survivors suffer from
long-term cognitive impairments after hospital discharge, leading to decreased life quality …
long-term cognitive impairments after hospital discharge, leading to decreased life quality …
Uncovering the underlying mechanisms of ketamine as a novel antidepressant
S Xu, X Yao, B Li, R Cui, C Zhu, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Major depressive disorder (MDD) is a devastating psychiatric disorder which exacts
enormous personal and social-economic burdens. Ketamine, an N-methyl-D-aspartate …
enormous personal and social-economic burdens. Ketamine, an N-methyl-D-aspartate …
[HTML][HTML] Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer's disease mouse model
Alzheimer's disease (AD) causes progressive age-related defects in memory and cognitive
function and has emerged as a major health and socio-economic concern in the US and …
function and has emerged as a major health and socio-economic concern in the US and …
Role of the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in the anti-psychotic effects of aripiprazole and sertindole in ketamine-induced schizophrenia-like …
Schizophrenia is a common mental disorder affecting patients' thoughts, behavior, and
cognition. Recently, the NRG1/ErbB4 signaling pathway emerged as a candidate …
cognition. Recently, the NRG1/ErbB4 signaling pathway emerged as a candidate …