Metal compounds against neglected tropical diseases

YC Ong, S Roy, PC Andrews, G Gasser - Chemical reviews, 2018 - ACS Publications
Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

Bioprospecting of Nitrogenous Heterocyclic Scaffolds with Potential Action for Neglected Parasitosis: A Review

SL Albino, JM da Silva, MS de C. Nobre… - Current …, 2020 - benthamdirect.com
Neglected parasitic diseases are a group of infections currently considered as a worldwide
concern. This fact can be attributed to the migration of these diseases to developed and …

Acetylated cashew gum-based nanoparticles for the incorporation of alkaloid epiisopiloturine

J do Amaral Rodrigues, AR de Araújo… - International journal of …, 2019 - Elsevier
The natural alkaloid epiisopiloturine has recently become the focus of study for various
medicinal properties, particularly for its anti-inflammatory and antischistosomal effect. The …

Bioorganometallic compounds as novel drug targets against schistosomiasis in sub-Saharan Africa: An alternative to Praziquantel?

CC Ndamse, P Masamba… - Advanced Pharmaceutical …, 2021 - pmc.ncbi.nlm.nih.gov
Human schistosomiasis is a disease that mostly plagues the destitute of various tropical and
sub-tropical countries, particularly in sub-Saharan Africa (SSA) and South America. It has …

Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidates

F d'Orchymont, J Hess, G Panic, M Jakubaszek… - …, 2018 - pubs.rsc.org
We present the design, synthesis, characterization and biological evaluation of new
ferrocenyl and ruthenocenyl derivatives of the organic antimalarial mefloquine, a drug also …

Prospecção científica e tecnológica de Pilocarpus microphyllus e do alcaloide epiisopiloturina com ênfase na atividade antileishmania

PS de Araujo Sousa, SS Nogueira… - Research, Society and …, 2021 - rsdjournal.org
Leishmaniasis is a parasitic disease that affects populations around the world, especially
those in develo** countries. Available therapy has serious adverse effects and reports of …

Recent studies on neglected drug design

NF de Sousa, L Scotti, GCS Rodrigues… - Current topics in …, 2021 - benthamdirect.com
Background: Neglected diseases require special attention when looking for new therapeutic
alternatives, as these are diseases of extreme complexity and severity that affect populations …

Theoretical UV-Vis spectra of tetracationic porphyrin: effects of environment on electronic spectral properties

ED Suarez, FCDA Lima, PM Dias… - Journal of Molecular …, 2019 - Springer
Electronic and spectroscopic properties of tetracationic 5, 10, 15, 20-tetrakis (1-methyl-4-
pyridyl)-21H, 23H-porphyrin (TMPyP) were investigated in the framework of the density …

Caracterização e incremento da cinética de dissolução do Protótipo Epiisopiloturina: uma abordagem físico-química

ACQM VIEIRA - 2017 - bdtd.ibict.br
A pilocarpina é um fitofármaco extratído do Jaborandi, utilizado no mundo inteiro.
Toneladas de folhas de jaborandi são empregadas na extração da pilocarpina, que possui …

Cálculos ab initio para Investigaçao de Propriedades Eletrônicas e Espectroscópicas de Complexos de Epiisopiloturina com Cu e Zn

ALE Virgino - 2017 - teses.usp.br
O entendimento das propriedades de complexos metálicos é de fundamental importância
para o desenvolvimento de fármacos. No entanto, tanto do ponto de vista experimental …