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P-bodies and stress granules: possible roles in the control of translation and mRNA degradation
CJ Decker, R Parker - Cold Spring Harbor perspectives …, 2012 - cshperspectives.cshlp.org
The control of translation and mRNA degradation is important in the regulation of eukaryotic
gene expression. In general, translation and steps in the major pathway of mRNA decay are …
gene expression. In general, translation and steps in the major pathway of mRNA decay are …
[HTML][HTML] mRNA cap regulation in mammalian cell function and fate
A Galloway, VH Cowling - Biochimica et Biophysica Acta (BBA)-Gene …, 2019 - Elsevier
In this review we explore the regulation of mRNA cap formation and its impact on
mammalian cells. The mRNA cap is a highly methylated modification of the 5′ end of RNA …
mammalian cells. The mRNA cap is a highly methylated modification of the 5′ end of RNA …
[HTML][HTML] Cytoplasmic RNA decay pathways-Enzymes and mechanisms
RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work
conducted over the last decades has defined the major mRNA decay pathways, as well as …
conducted over the last decades has defined the major mRNA decay pathways, as well as …
Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA
Chemical modification of transcripts with 5′ caps occurs in all organisms. Here, we report a
systems-level mass spectrometry-based technique, CapQuant, for quantitative analysis of an …
systems-level mass spectrometry-based technique, CapQuant, for quantitative analysis of an …
Thermostability, tunability, and tenacity of RNA as rubbery anionic polymeric materials in nanotechnology and nanomedicine—specific cancer targeting with …
RNA nanotechnology is the bottom-up self-assembly of nanometer-scale architectures,
resembling LEGOs, composed mainly of RNA. The ideal building material should be (1) …
resembling LEGOs, composed mainly of RNA. The ideal building material should be (1) …
Competing and noncompeting activities of miR-122 and the 5′ exonuclease Xrn1 in regulation of hepatitis C virus replication
Hepatitis C virus (HCV) replication is dependent on microRNA 122 (miR-122), a liver-
specific microRNA that recruits Argonaute 2 to the 5′ end of the viral genome, stabilizing it …
specific microRNA that recruits Argonaute 2 to the 5′ end of the viral genome, stabilizing it …
mRNA decap** factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription
We report a function of human mRNA decap** factors in control of transcription by RNA
polymerase II. Decap** proteins Edc3, Dcp1a, and Dcp2 and the termination factor TTF2 …
polymerase II. Decap** proteins Edc3, Dcp1a, and Dcp2 and the termination factor TTF2 …
New insights into decap** enzymes and selective mRNA decay
E Grudzien‐Nogalska… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Removal of the 5′ end cap is a critical determinant controlling mRNA stability and efficient
gene expression. Removal of the cap is exquisitely controlled by multiple direct and indirect …
gene expression. Removal of the cap is exquisitely controlled by multiple direct and indirect …
A mammalian pre-mRNA 5′ end cap** quality control mechanism and an unexpected link of cap** to pre-mRNA processing
Recently, we reported that two homologous yeast proteins, Rai1 and Dxo1, function in a
quality control mechanism to clear cells of incompletely 5′ end-capped messenger RNAs …
quality control mechanism to clear cells of incompletely 5′ end-capped messenger RNAs …
Multiple Nudix family proteins possess mRNA decap** activity
MG Song, S Bail, M Kiledjian - Rna, 2013 - rnajournal.cshlp.org
RNA decap** is an important contributor to gene expression and is a critical determinant
of mRNA decay. The recent demonstration that mammalian cells harbor at least two distinct …
of mRNA decay. The recent demonstration that mammalian cells harbor at least two distinct …