Bone is a unique tissue composed of numerous cell types entombed within a mineralized
matrix each with its own unique functions. While the majority of the matrix is composed of …

The mechanical properties of bone material are determined by the relative amounts of its 3
major constituents: mineral, water, and organics (mainly type I collagen); by the quality of …

Infrared imaging analysis of iliac crest biopsy specimens from patients with osteoporotic and
multiple spontaneous fractures shows significant differences in the spatial variation of the …

Osteoporosis is a common disease with a strong genetic component. Twin studies have
shown that genetic factors play an important role in regulating bone mineral density (BMD) …

Genetic factors play an important role in the pathogenesis of osteoporosis and several
candidate gene polymorphisms have been implicated in the regulation of this process. One …

Peak bone mass is an important risk factor for the development of osteoporosis in later life.
Previous work has suggested that genetic, intrauterine, and environmental factors all …

Background Cruciate ligament ruptures and shoulder dislocations are often caused by
trauma, but predisposing intrinsic factors might also influence the risk. These injuries are …

Abstract Aims/hypothesis The Pro12Ala polymorphism of peroxisome proliferator-activated
receptor (PPAR) γ has been consistently associated with Type 2 diabetes. The rare Ala12 …

Zoledronic acid to prevent bone loss in the first 6 months after renal transplantation.
Background Bisphosphonates can prevent bone mineral density loss after renal …

A meta-analysis of studies was conducted involving 24,511 participants with 7,864 fractures
in which polymorphisms in the 5′ flank of COL1A1 (rs1107946, rs2412298, and …