The secretion of glucocorticoids (GCs) is a classic endocrine response to stress. Despite
that, it remains controversial as to what purpose GCs serve at such times. One view …

In response to stress, the brain activates several neuropeptide-secreting systems. This
eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed …

Brain Corticosteroid Receptor Balance in Health and Disease* | Endocrine Reviews | Oxford
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Signs and symptoms that are characteristic for depression include changes in the setpoint of
the hypothalamic-pituitary-adrenocortical (HPA) system, which in the majority of these …

The past decade has seen several critical advances in our understanding of hypothalamic–
pituitary–adrenal (HPA) axis regulation. Homeostatic physiological circuits need to integrate …

Cognitive deficits following acute administration of corticosteroids have been described in
experimental animals and humans. In both populations, an inverted-U shape relationship …

Reference to glucocorticoids as “stress hormones” has been growing in prevalence in the
literature, including in comparative and environmental endocrinology. Although …

I. Introduction P AST studies of antidepressants have focused almost exclusively on their
effects on the metabolism and receptors of monoamine neurotransmitters in various brain …

Clinical and preclinical studies have gathered substantial evidence that alterations of the
stress hormone system play a major, causal role in the development of depression. In this …

Regulation of stress reactivity is a fundamental priority of all organisms. Stress responses
are critical for survival, yet can also cause physical and psychological damage. This review …