As the elderly population increases, a growing number of individuals suffer from age‐
associated neurodegenerative diseases, such as A lzheimer's disease (AD) and P …

Abstract With only 1.3− 4.3% in total hepatic CYP content, human CYP2D6 can metabolize
more than 160 drugs. It is a highly polymorphic enzyme and subject to marked inhibition by …

Based on the combined technologies of atomic force microscopy, X‐ray
diffraction/scattering, Fourier transform infrared spectra analysis, etc., it is demonstrated that …

Neuropeptides are small proteins broadly expressed throughout the central nervous system,
which act as neurotransmitters, neuromodulators and neuroregulators. Growing evidence …

Two series of fluorinated chalcones containing morpholine and imidazole‐based
compounds (f1–f8) were synthesized and evaluated for recombinant human monoamine …

It is reported in this study the effect of isolates from leaves of Aristotelia chilensis as inhibitors
of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and tyrosinase enzymes. The …

Abstract Ethnopharmacological relevance Leaves from Psychotria poeppigiana Müll.
Arg.(accepted as Palicourea tomentosa (Aubl.) Borhidi), Rubiaceae, has traditionally been …

The aggregation into amyloid fibrils of amyloid-β (Aβ) peptides is a hallmark of Alzheimer's
disease. A variety of Aβ peptides have been discovered in vivo, with pyroglutamate-modified …

Alzheimer's disease (AD) is an irreversible neurodegenerative disease, clinically
characterized by progressive impairments of memory and cognition. The hallmarks of AD …

The aggregation of the amyloid β (Aβ) peptide is a major hallmark of Alzheimer's disease.
This peptide can aggregate into oligomers, proto-fibrils and mature fibrils, which eventually …