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Mice with endogenous TDP‐43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis
P Fratta, P Sivakumar, J Humphrey, K Lo… - The EMBO …, 2018 - embopress.org
TDP‐43 (encoded by the gene TARDBP) is an RNA binding protein central to the
pathogenesis of amyotrophic lateral sclerosis (ALS). However, how TARDBP mutations …
pathogenesis of amyotrophic lateral sclerosis (ALS). However, how TARDBP mutations …
[HTML][HTML] Chronic peripheral inflammation causes a region-specific myeloid response in the central nervous system
P Süß, A Hoffmann, T Rothe, Z Ouyang, W Baum… - Cell Reports, 2020 - cell.com
Systemic immune dysregulation contributes to the development of neuropsychiatric and
neurodegenerative diseases. The precise effect of chronic peripheral immune stimulation on …
neurodegenerative diseases. The precise effect of chronic peripheral immune stimulation on …
Presynaptic homeostasis opposes disease progression in mouse models of ALS-like degeneration: evidence for homeostatic neuroprotection
BO Orr, AG Hauswirth, B Celona, RD Fetter, G Zunino… - Neuron, 2020 - cell.com
Progressive synapse loss is an inevitable and insidious part of age-related
neurodegenerative disease. Typically, synapse loss precedes symptoms of cognitive and …
neurodegenerative disease. Typically, synapse loss precedes symptoms of cognitive and …
Identification of the functions and prognostic values of RNA binding proteins in bladder cancer
Y Wu, Z Liu, X Wei, H Feng, B Hu, B Liu, Y Luan… - Frontiers in …, 2021 - frontiersin.org
Post-transcriptional regulation plays a leading role in gene regulation and RNA binding
proteins (RBPs) are the most important posttranscriptional regulatory protein. RBPs had …
proteins (RBPs) are the most important posttranscriptional regulatory protein. RBPs had …
The role of zinc supplementation on the metallothionein system in children with autism spectrum disorder
NA Meguid, G Bjørklund, OH Gebril, MD Doşa… - Acta Neurologica …, 2019 - Springer
The present research was carried out to elucidate the role of zinc (Zn) supplementation on
the plasma concentration and gene expression, as well as the effects on cognitive-motor …
the plasma concentration and gene expression, as well as the effects on cognitive-motor …
Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106
B Celona, J Dollen, SC Vatsavayai, R Kashima… - Elife, 2017 - elifesciences.org
Expanded GGGGCC repeats in the first intron of the C9orf72 gene represent the most
common cause of familial amyotrophic lateral sclerosis (ALS), but the mechanisms …
common cause of familial amyotrophic lateral sclerosis (ALS), but the mechanisms …
Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP
The multi-domain transcriptional coactivators CBP/p300 integrate a multitude of signaling
inputs, interacting with more than 400 proteins via one or more of their globular domains …
inputs, interacting with more than 400 proteins via one or more of their globular domains …
Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106
DM Anderson, J Cannavino, H Li, KM Anderson… - Proceedings of the …, 2016 - pnas.org
Innervation of skeletal muscle by motor neurons occurs through the neuromuscular junction,
a cholinergic synapse essential for normal muscle growth and function. Defects in nerve …
a cholinergic synapse essential for normal muscle growth and function. Defects in nerve …
Genome-wide association study for four measures of epigenetic age acceleration and two epigenetic surrogate markers using DNA methylation data from Taiwan …
WY Lin - Human molecular genetics, 2022 - academic.oup.com
To highlight the genetic architecture for epigenetic aging, McCartney et al. recently identified
137 significant single-nucleotide polymorphisms based on genome-wide association study …
137 significant single-nucleotide polymorphisms based on genome-wide association study …
[HTML][HTML] A diagnostic gene-expression signature in fibroblasts of amyotrophic lateral sclerosis
G Morello, V La Cognata, M Guarnaccia, V La Bella… - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease with
limited treatment options. Diagnosis can be difficult due to the heterogeneity and non …
limited treatment options. Diagnosis can be difficult due to the heterogeneity and non …