[HTML][HTML] A comprehensive review of artificial intelligence and network based approaches to drug repurposing in Covid-19

F Ahmed, AM Soomro, ARC Salih… - Biomedicine & …, 2022 - Elsevier
Conventional drug discovery and development is tedious and time-taking process; because
of which it has failed to keep the required pace to mitigate threats and cater demands of viral …

Endometriosis in the era of precision medicine and impact on sexual and reproductive health across the lifespan and in diverse populations

LC Giudice, TT Oskotsky, S Falako… - The FASEB …, 2023 - Wiley Online Library
Endometriosis is a common estrogen‐dependent disorder wherein uterine lining tissue
(endometrium) is found mainly in the pelvis where it causes inflammation, chronic pelvic …

A review on computer‐aided chemogenomics and drug repositioning for rational COVID‐19 drug discovery

S Maghsoudi, B Taghavi Shahraki… - Chemical biology & …, 2022 - Wiley Online Library
Application of materials capable of energy harvesting to increase the efficiency and
environmental adaptability is sometimes reflected in the ability of discovery of some traces in …

[HTML][HTML] Clofazimine: a journey of a drug

J Xu, A Koval, VL Katanaev - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Among different strategies to develop novel therapies, drug repositioning (aka repurposing)
aims at identifying new uses of an already approved or investigational drug. This approach …

[HTML][HTML] Drug repurposing in psoriasis, performed by reversal of disease-associated gene expression profiles

F Ahmed, SG Ho, A Samantasinghar, FH Memon… - Computational and …, 2022 - Elsevier
Psoriasis is a skin disease which results in scales on the skin caused by flaky patches.
Psoriasis is triggered by various conditions such as drug reactions, trauma, and skin …

Reciprocal enhancement of SARS-CoV-2 and influenza virus replication in human pluripotent stem cell-derived lung organoids

MJ Kim, S Kim, H Kim, D Gil, HJ Han… - Emerging Microbes & …, 2023 - Taylor & Francis
Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza
A virus (FLUAV) coinfections were associated with severe respiratory failure and more …

[HTML][HTML] Potential of microneedle systems for COVID-19 vaccination: current trends and challenges

J Hassan, C Haigh, T Ahmed, MJ Uddin, DB Das - Pharmaceutics, 2022 - mdpi.com
To prevent the coronavirus disease 2019 (COVID-19) pandemic and aid restoration to
prepandemic normality, global mass vaccination is urgently needed. Inducing herd immunity …

Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer

F Haderk, YT Chou, L Cech… - Nature …, 2024 - nature.com
Targeted therapy is effective in many tumor types including lung cancer, the leading cause
of cancer mortality. Paradigm defining examples are targeted therapies directed against non …

Molecular docking as a tool for the discovery of novel insight about the role of acid sphingomyelinase inhibitors in SARS-CoV-2 infectivity

SS Alkafaas, AM Abdallah, MH Hassan, AM Hussien… - BMC public health, 2024 - Springer
Abstract Recently, COVID-19, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) and its variants, caused> 6 million deaths. Symptoms included respiratory …

Identifying therapeutic candidates for endometriosis through a transcriptomics-based drug repositioning approach

TT Oskotsky, A Bhoja, D Bunis, BL Le, AS Tang, I Kosti… - Iscience, 2024 - cell.com
Existing medical treatments for endometriosis-related pain are often ineffective,
underscoring the need for new therapeutic strategies. In this study, we applied a …