Benzodiazepines (BZs) 2 are used clinically as muscle relaxants, anticonvulsants,
anxiolytics, and sedativehypnotics. These effects are mediated primarily via the central BZ …

Due to its channel-like properties, the peripheral-type benzodiazepine receptor (PBR) has
been renamed the translocator protein (TSPO). In eukaryotes, the TSPO is primarily located …

Hexokinase II is often highly expressed in poorly differentiated and rapidly growing tumors
that exhibit a high rate of aerobic glycolysis. Hexokinase II binds to the mitochondrial …

Peripheral-type benzodiazepine receptors (PBRs) are abundant in the cardiovascular
system. In the cardiovascular lumen, PBRs are present in platelets, erythrocytes …

ACTH does not affect delivery of cholesterol to mitochondria but results in accumulation of
cholesterol in OMM and a corresponding loss of IMM cholesterol. Cholesterol-P450scc …

Peptide hormones and cAMP acutely stimulate steroid biosynthesis by accelerating the
transport of cholesterol into the mitochondria. The peripheral-type benzodiazepine receptor …

Optimal early development in most species is dependent upon a stable relationship
between the mother and her infant. The research described here focuses on the reciprocal …

Classically, the production of glucocorticoids by the adrenal gland is thought to be controlled
exclusively by adrenocorticotropic hormone (ACTH). However, there are several examples …

Abstract Translocator protein (TSPO; 18 kDA) is a high-affinity cholesterol-binding protein
that is integrally involved in cholesterol transfer from intracellular stores into mitochondria …

The central nervous system synthesizes steroids which regulate the development and
function of neurons and glia and have neuroprotective properties. The first step in this …