Meta-inflammation and metabolic reprogramming of macrophages in diabetes and obesity: the importance of metabolites
S Russo, M Kwiatkowski, N Govorukhina… - Frontiers in …, 2021 - frontiersin.org
Diabetes mellitus type II and obesity are two important causes of death in modern society.
They are characterized by low-grade chronic inflammation and metabolic dysfunction (meta …
They are characterized by low-grade chronic inflammation and metabolic dysfunction (meta …
Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function
A key metabolic activity of the gut microbiota is the fermentation of non-digestible
carbohydrate, which generates short-chain fatty acids (SCFAs) as the principal end …
carbohydrate, which generates short-chain fatty acids (SCFAs) as the principal end …
β-Hydroxybutyrate: a signaling metabolite
JC Newman, E Verdin - Annual review of nutrition, 2017 - annualreviews.org
Various mechanisms in the mammalian body provide resilience against food deprivation
and dietary stress. The ketone body β-hydroxybutyrate (BHB) is synthesized in the liver from …
and dietary stress. The ketone body β-hydroxybutyrate (BHB) is synthesized in the liver from …
Epigenetics of type 2 diabetes mellitus and weight change—a tool for precision medicine?
Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …
Adipose tissue browning and metabolic health
Accumulation of excess white adipose tissue (WAT) has deleterious consequences for
metabolic health. The activation of brown adipose tissue (BAT), the primary organ for heat …
metabolic health. The activation of brown adipose tissue (BAT), the primary organ for heat …
A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue
Epigenetic mechanisms are implicated in gene regulation and the development of different
diseases. The epigenome differs between cell types and has until now only been …
diseases. The epigenome differs between cell types and has until now only been …
The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging
ME Walsh, A Bhattacharya, K Sataranatarajan… - Aging cell, 2015 - Wiley Online Library
Sarcopenia, the loss of skeletal muscle mass and function during aging, is a major
contributor to disability and frailty in the elderly. Previous studies found a protective effect of …
contributor to disability and frailty in the elderly. Previous studies found a protective effect of …
β-hydroxybutyrate: much more than a metabolite
JC Newman, E Verdin - Diabetes research and clinical practice, 2014 - Elsevier
The ketone body β-hydroxybutyrate (βOHB) is a convenient carrier of energy from
adipocytes to peripheral tissues during fasting or exercise. However, βOHB is more than just …
adipocytes to peripheral tissues during fasting or exercise. However, βOHB is more than just …
Crosstalk between adipokines and myokines in fat browning
Skeletal muscle is the largest organ determining whole‐body insulin sensitivity and
metabolic homoeostasis. Adaptive changes of skeletal muscle in response to physical …
metabolic homoeostasis. Adaptive changes of skeletal muscle in response to physical …
[HTML][HTML] HDAC3 deficiency protects against acute lung injury by maintaining epithelial barrier integrity through preserving mitochondrial quality control
N Li, B Liu, R **ong, G Li, B Wang, Q Geng - Redox Biology, 2023 - Elsevier
Sepsis is one common cause of acute lung injury (ALI) and acute respiratory distress
syndrome (ARDS), which is closely associated with high mortality in intensive care units …
syndrome (ARDS), which is closely associated with high mortality in intensive care units …