Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …

Pyrazole derivatives, as a class of heterocyclic compounds, possess unique chemical
structures that confer them with a broad spectrum of pharmacological activities. They have …

Recently, scientists developed a powerful strategy called “one drug-multiple targets” to
discover vital and unique therapies to fight the most challenging diseases. Novel derivatives …

The strategy of utilizing nitrogen compounds in various biological applications has recently
emerged as a powerful approach to exploring novel classes of therapeutics to face the …

A series of new heterocycle hybrids incorporating pyrazole and isoxazoline rings was
successfully synthesized, characterized, and evaluated for their antimicrobial responses …

Heterocycles are a privileged motif that appears as a momentous objective in medicinal
chemistry. An important class of compounds for drug discovery and design is indole and its …

Based on previous developments of our research programs in trying to find new compounds
with multiple biological targets such as antioxidant, anti-diabetic, anti-Alzheimer's, and anti …

Pyrazole-containing compounds represent one of the most influential families of N-
heterocycles due to their proven applicability and versatility as synthetic intermediates in …

In this work, two chlorophenols with particular toxicities were transformed into their 14
corresponding coumarins (CMs). Their chemical structures were confirmed by examining the …

Deregulation of various protein kinases is considered as one of the important factors
resulting in cancer development and metastasis, thus multi-targeting the kinase family is one …