Microglial cells are the major immune cells of the central nervous system (CNS), and directly
react to neurodegeneration, but other immune cell types are also able to react to pathology …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …

Individuals who are diagnosed with amyotrophic lateral sclerosis (ALS) today face the same
historically intransigent problem that has existed since the initial description of the disease in …

Glial cells are abundant in the CNS and are essential for brain development and
homeostasis. These cells also regulate tissue recovery after injury and their dysfunction is a …

Neuroinflammation is a common pathological feature of many neurodegenerative diseases,
including amyotrophic lateral sclerosis (ALS), and is characterised by activated CNS …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are
neurodegenerative diseases that overlap in their clinical presentation, pathology and …

The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, involving
neuroinflammation and T cell infiltration in the central nervous system. However, the …

The brain, long thought to be isolated from the peripheral immune system, is increasingly
recognized to be integrated into a systemic immunological network. These conduits of …

Alzheimer's disease (AD) represents an urgent public health mandate. AD is no longer
considered a neural-centric disease; rather, a plethora of recent studies strongly implicate a …