Docking is now routine in virtual screening or lead optimization for drug screening and
design. The number of papers related to docking has dramatically increased over the past …

Carboxylesterases are a multigene family of mammalian enzymes widely distributed
throughout the body that catalyze the hydrolysis of esters, amides, thioesters, and …

The aim of docking is to accurately predict the structure of a ligand within the constraints of a
receptor binding site and to correctly estimate the strength of binding. We discuss, in detail …

Mammalian carboxylesterase (CES or Ces) genes encode enzymes that participate in
xenobiotic, drug, and lipid metabolism in the body and are members of at least five gene …

Drug discovery and development is a high-risk enterprise that requires significant
investments in capital, time and scientific expertise. The studies of xenobiotic metabolism …

Human carboxylesterases (CESs) are serine hydrolases that are responsible for the phase I
metabolism of an assortment of ester, amide, thioester, carbonate, and carbamate …

As the use of nanoparticles (NPs) is increasing, the potential toxicity and behavior of NPs in
living systems need to be better understood. Our goal was to evaluate the developmental …

In the current era of modern drug design & development via computer-aided drug design,
the potential role of computational software tools is widely enlarged in use. Computer-based …

Amplex Red is a fluorescent probe that is widely used to detect hydrogen peroxide (H 2 O 2)
in a reaction where it is oxidised to resorufin by horseradish peroxidase (HRP) as a catalyst …

Carboxylesterases (CES) are an important class of enzymes involved in the hydrolysis of a
range of chemicals and show large inter-individual variability in vitro. An extensive literature …