The cGAS–STING pathway as a therapeutic target in inflammatory diseases
The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
Role of the cGAS–STING pathway in systemic and organ-specific diseases
Cells are equipped with numerous sensors that recognize nucleic acids, which probably
evolved for defence against viruses. Once triggered, these sensors stimulate the production …
evolved for defence against viruses. Once triggered, these sensors stimulate the production …
The immunology of systemic lupus erythematosus
Understanding the pathogenesis and clinical manifestations of systemic lupus
erythematosus (SLE) has been a great challenge. Reductionist approaches to understand …
erythematosus (SLE) has been a great challenge. Reductionist approaches to understand …
Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
Signaling pathways and intervention therapies in sepsis
Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …
systemic inflammatory and immune response to infection. Over decades, advanced …
[ספר][B] Examining illiberal trends and anti-EU politics in east Central Europe from a domestic perspective: State of research and outline of the book
LH Anders, A Lorenz - 2021 - library.oapen.org
In East Central Europe (ECE), democracy and the rule of law are under siege, most notably
in Hungary and Poland and, to a lesser extent, also in the Czech Republic and Slovakia …
in Hungary and Poland and, to a lesser extent, also in the Czech Republic and Slovakia …
The STING1 network regulates autophagy and cell death
Cell death and immune response are at the core of life. In past decades, the endoplasmic
reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a …
reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a …
Regulating IRFs in IFN driven disease
The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal
roles in many aspects of the immune response, including immune cell development and …
roles in many aspects of the immune response, including immune cell development and …
The cGAS-STING pathway: a promising immunotherapy target
With the continuous development of immunotherapy, researchers have paid more attention
to the specific immune regulatory mechanisms of various immune responses in different …
to the specific immune regulatory mechanisms of various immune responses in different …
Research advances in how the cGAS-STING pathway controls the cellular inflammatory response
D Wan, W Jiang, J Hao - Frontiers in immunology, 2020 - frontiersin.org
Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …