The invention of silica-based bioactive glass in the late 1960s has sparked significant
interest in exploring a wide range of silicon-containing biomaterials from the macroscale to …

Biological barriers to drug transport prevent successful accumulation of nanotherapeutics
specifically at diseased sites, limiting efficacious responses in disease processes ranging …

Stimulus-cleavable nanoscale drug delivery systems are receiving significant attention
owing to their capability of achieving exquisite control over drug release via the exposure to …

The therapeutic efficacy of systemic drug-delivery vehicles depends on their ability to evade
the immune system, cross the biological barriers of the body and localize at target tissues …

The controlled delivery of nucleic acids to selected tissues remains an inefficient process
mired by low transfection efficacy, poor scalability because of varying efficiency with cell type …

Nanoparticles for biomedical applications are generally formed by bottom-up approaches
such as self-assembly, emulsification and precipitation. But these methods usually have …

In the past two decades, porous silicon (PSi) has attracted increasing attention for its
potential biomedical applications. With its controllable geometry, tunable nanoporous …

Intracellular delivery of advanced therapeutics, including biologicals and supramolecular
agents, is complex because of the natural biological barriers that have evolved to protect the …

Magnetic resonance imaging contrast agents are currently designed by modifying their
structural and physiochemical properties to improve relaxivity and to enhance image …

Silicon is one of the most abundant chemical elements found on the Earth. Due to its unique
chemical and physical properties, silicon based materials and their oxides (eg silica) have …