Clinical practice guidelines (CPGs) aim to improve the quality of care, reduce unjustified
practice variations and reduce healthcare costs. In order for them to be effective, clinical …

Objective: The objective of this review is to summarize the state of the art of clinical decision
support (CDS) circa 1990, review progress in the 25 year interval from that time, and provide …

This chapter discusses information technology that provides health-care workers and
patients with situation-specific advice that can inform their decision making. The intricacies …

Arden Syntax is a widely recognized standard for representing clinical and scientific
knowledge in an executable format. It has a history that reaches back until 1989 and is …

Abstract The SAGE (Standards-Based Active Guideline Environment) project was formed to
create a methodology and infrastructure required to demonstrate integration of decision …

Standards-based, computable knowledge representations for eligibility criteria are
increasingly needed to provide computer-based decision support for automated research …

Formalizing eligibility criteria in a computer-interpretable language would facilitate eligibility
determination for study subjects and the identification of studies on similar patient …

Formal, computer-interpretable representations of eligibility criteria would allow computers
to better support key clinical research and care use cases such as eligibility determination …

Background There are several challenges in encoding guideline knowledge in a form that is
portable to different clinical sites, including the heterogeneity of clinical decision support …

The need for formal representations of eligibility criteria for clinical trials–and for
phenoty** more generally–has been recognized for some time. Indeed, the availability of …