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malERA: an updated research agenda for malaria elimination and eradication
Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …
overwhelming health, equity, and economic benefits. WHO and countries are setting …
Parasite recognition and signaling mechanisms in innate immune responses to malaria
DC Gowda, X Wu - Frontiers in immunology, 2018 - frontiersin.org
Malaria caused by the Plasmodium family of parasites, especially P. falciparum and P. vivax,
is a major health problem in many countries in the tropical and subtropical regions of the …
is a major health problem in many countries in the tropical and subtropical regions of the …
[HTML][HTML] Functional profiling of a Plasmodium genome reveals an abundance of essential genes
The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …
development through the identification of essential genes and pathways, we have measured …
The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle
INTRODUCTION Plasmodium parasites, the causative agent of malaria, are single-celled
organisms with distinct morphological developmental stages each specialized to inhabit …
organisms with distinct morphological developmental stages each specialized to inhabit …
Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution
Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …
continues to afflict hundreds of millions of people every year. Infections with malaria …
Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites
Single-cell RNA-sequencing is revolutionising our understanding of seemingly
homogeneous cell populations but has not yet been widely applied to single-celled …
homogeneous cell populations but has not yet been widely applied to single-celled …
Sexual differentiation in human malaria parasites is regulated by competition between phospholipid metabolism and histone methylation
For Plasmodium falciparum, the most widespread and virulent malaria parasite that infects
humans, persistence depends on continuous asexual replication in red blood cells, while …
humans, persistence depends on continuous asexual replication in red blood cells, while …
A knockout screen of ApiAP2 genes reveals networks of interacting transcriptional regulators controlling the Plasmodium life cycle
A family of apicomplexa-specific proteins containing AP2 DNA-binding domains (ApiAP2s)
was identified in malaria parasites. This family includes sequence-specific transcription …
was identified in malaria parasites. This family includes sequence-specific transcription …
Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites
Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must
navigate the host skin and vasculature to infect the liver. This journey requires distinct …
navigate the host skin and vasculature to infect the liver. This journey requires distinct …
Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution
Elucidation of the evolutionary history and interrelatedness of Plasmodium species that
infect humans has been hampered by a lack of genetic information for three human-infective …
infect humans has been hampered by a lack of genetic information for three human-infective …