Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies
Most patients survive acute myocardial infarction (MI). Yet this encouraging development
has certain drawbacks: heart failure (HF) prevalence is increasing and patients affected tend …
has certain drawbacks: heart failure (HF) prevalence is increasing and patients affected tend …
Metabolic remodelling in heart failure
The heart consumes large amounts of energy in the form of ATP that is continuously
replenished by oxidative phosphorylation in mitochondria and, to a lesser extent, by …
replenished by oxidative phosphorylation in mitochondria and, to a lesser extent, by …
Cardiovascular metabolomics
Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics,
one of the newer omics technologies, has emerged as a powerful tool for defining changes …
one of the newer omics technologies, has emerged as a powerful tool for defining changes …
Glucose metabolism in cardiac hypertrophy and heart failure
Heart failure is one of the leading causes of death worldwide and has been singled out as
an emerging epidemic. 1, 2 With a 5-year survival rate of 50%, heart failure poses a …
an emerging epidemic. 1, 2 With a 5-year survival rate of 50%, heart failure poses a …
Metabolic coordination of physiological and pathological cardiac remodeling
Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …
YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload
T Kashihara, R Mukai, S Oka, P Zhai, Y Nakada… - The Journal of clinical …, 2022 - jci.org
The heart utilizes multiple adaptive mechanisms to maintain pump function. Compensatory
cardiac hypertrophy reduces wall stress and oxygen consumption, thereby protecting the …
cardiac hypertrophy reduces wall stress and oxygen consumption, thereby protecting the …
Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes
The network for cardiac fuel metabolism contains intricate sets of interacting pathways that
result in both ATP-producing and non–ATP-producing end points for each class of energy …
result in both ATP-producing and non–ATP-producing end points for each class of energy …
Implications of altered ketone metabolism and therapeutic ketosis in heart failure
Despite existing therapy, patients with heart failure (HF) experience substantial morbidity
and mortality, highlighting the urgent need to identify novel pathophysiological mechanisms …
and mortality, highlighting the urgent need to identify novel pathophysiological mechanisms …
Normalization of NAD+ Redox Balance as a Therapy for Heart Failure
Background: Impairments of mitochondrial function in the heart are linked intricately to the
development of heart failure, but there is no therapy for mitochondrial dysfunction. Methods …
development of heart failure, but there is no therapy for mitochondrial dysfunction. Methods …
Integration of cellular bioenergetics with mitochondrial quality control and autophagy
Bioenergetic dysfunction is emerging as a cornerstone for establishing a framework for
understanding the pathophysiology of cardiovascular disease, diabetes, cancer and …
understanding the pathophysiology of cardiovascular disease, diabetes, cancer and …