Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

Due to their key role in the pathogenesis of cancer through the regulation of apoptosis, the B-
cell leukemia/lymphoma-2 (BCL-2) family proteins have been an attractive target for cancer …

Immunotherapies have significantly improved the survival of patients in many cancers over
the last decade. However, primary and secondary resistances are encountered in most …

The potential of gossypol and of its R-(−)-enantiomer (R-(−)-gossypol acetic acid, AT-101),
has been evaluated for treatment of cancer as an independent agent and in combination …

As a solid tumor with high glycolytic activity, hepatocellular carcinoma (HCC) produces
excess lactic acid and increases extracellular acidity, thus forming a unique …

Lactate significantly impacts immune cell function in sepsis and septic shock, transcending
its traditional view as just a metabolic byproduct. This review summarizes the role of lactate …

Despite the vast amounts of research and remarkable discoveries that have been made in
recent decades, cancer remains a leading cause of death and a major public health concern …

Purpose In recent years, a variety of nanoparticles with excellent anticancer and delivery
properties have emerged for cancer therapy. However, potential toxicity, high production …

Resistance to anticancer agents and apoptosis results in cancer relapse and is associated
with cancer mortality. Substantial data have provided convincing evidence establishing that …

Recent advances in understanding the tumor's biology in line with a constantly growing
number of innovative technologies have prompted characterization of patients' individual …