Adult hippocampal neurogenesis in major depressive disorder and Alzheimer's disease
Depression and dementia are major public health problems. Major depressive disorder
(MDD) and Alzheimer's disease (AD) reciprocally elevate the risk for one another. No …
(MDD) and Alzheimer's disease (AD) reciprocally elevate the risk for one another. No …
Sex differences in the epilepsies and associated comorbidities: implications for use and development of pharmacotherapies
The epilepsies are common neurologic disorders characterized by spontaneous recurrent
seizures. Boys, girls, men, and women of all ages are affected by epilepsy and, in many …
seizures. Boys, girls, men, and women of all ages are affected by epilepsy and, in many …
[HTML][HTML] Adult neurogenesis, human after all (again): Classic, optimized, and future approaches
In this perspective article, we reflect on the recent debate about the existence of human
neurogenesis and discuss direct, and also indirect, support for the ongoing formation, and …
neurogenesis and discuss direct, and also indirect, support for the ongoing formation, and …
MicroRNAs as potential biomarkers in temporal lobe epilepsy and mesial temporal lobe epilepsy
B Martinez, PV Peplow - Neural Regeneration Research, 2023 - journals.lww.com
Temporal lobe epilepsy is the most common form of focal epilepsy in adults, accounting for
one third of all diagnosed epileptic patients, with seizures originating from or involving …
one third of all diagnosed epileptic patients, with seizures originating from or involving …
An excitatory and epileptogenic effect of dentate gyrus mossy cells in a mouse model of epilepsy
The sparse activity of hippocampal dentate gyrus (DG) granule cells (GCs) is thought to be
critical for cognition and behavior, whereas excessive DG activity may contribute to …
critical for cognition and behavior, whereas excessive DG activity may contribute to …
[HTML][HTML] Robust chronic convulsive seizures, high frequency oscillations, and human seizure onset patterns in an intrahippocampal kainic acid model in mice
Intrahippocampal kainic acid (IHKA) has been widely implemented to simulate temporal
lobe epilepsy (TLE), but evidence of robust seizures is usually limited. To resolve this …
lobe epilepsy (TLE), but evidence of robust seizures is usually limited. To resolve this …
Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway
L Lu, H Wang, X Liu, L Tan, X Qiao, J Ni, Y Sun… - Journal of …, 2021 - Springer
Background Neuropsychiatric systemic lupus erythematosus (NPSLE) is a severe
complication, which involves pathological damage to the brain and cognitive function …
complication, which involves pathological damage to the brain and cognitive function …
Early seizure activity accelerates depletion of hippocampal neural stem cells and impairs spatial discrimination in an Alzheimer's disease model
CH Fu, DM Iascone, I Petrof, A Hazra, X Zhang… - Cell reports, 2019 - cell.com
Adult hippocampal neurogenesis has been reported to be decreased, increased, or not
changed in Alzheimer's disease (AD) patients and related transgenic mouse models. These …
changed in Alzheimer's disease (AD) patients and related transgenic mouse models. These …
Bcl11 transcription factors regulate cortical development and function
R Simon, C Wiegreffe, S Britsch - Frontiers in molecular neuroscience, 2020 - frontiersin.org
Transcription factors regulate multiple processes during brain development and in the adult
brain, from brain patterning to differentiation and maturation of highly specialized neurons as …
brain, from brain patterning to differentiation and maturation of highly specialized neurons as …
Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy
The hippocampal CA2 region, an area important for social memory, has been suspected to
play a role in temporal lobe epilepsy (TLE) because of its resistance to degeneration …
play a role in temporal lobe epilepsy (TLE) because of its resistance to degeneration …