HIV-1: to splice or not to splice, that is the question
A Emery, R Swanstrom - Viruses, 2021 - mdpi.com
The transcription of the HIV-1 provirus results in only one type of transcript—full length
genomic RNA. To make the mRNA transcripts for the accessory proteins Tat and Rev, the …
genomic RNA. To make the mRNA transcripts for the accessory proteins Tat and Rev, the …
Multiple functions of heterogeneous nuclear ribonucleoproteins in the positive single-stranded RNA virus life cycle
J Wang, D Sun, M Wang, A Cheng, Y Zhu… - Frontiers in …, 2022 - frontiersin.org
The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a diverse family of RNA
binding proteins that are implicated in RNA metabolism, such as alternative splicing, mRNA …
binding proteins that are implicated in RNA metabolism, such as alternative splicing, mRNA …
hnRNP A1 dysfunction alters RNA splicing and drives neurodegeneration in multiple sclerosis (MS)
HE Salapa, PA Thibault, CD Libner, Y Ding… - Nature …, 2024 - nature.com
Neurodegeneration is the primary driver of disease progression in multiple sclerosis (MS)
resulting in permanent disability, creating an urgent need to discover its underlying …
resulting in permanent disability, creating an urgent need to discover its underlying …
[HTML][HTML] Viral hijacking of hnRNPH1 unveils a G-quadruplex-driven mechanism of stress control
Viral genomes are enriched with G-quadruplexes (G4s), non-canonical structures formed in
DNA or RNA upon assembly of four guanine stretches into stacked quartets. Because of …
DNA or RNA upon assembly of four guanine stretches into stacked quartets. Because of …
ESCO2 promotes lung adenocarcinoma progression by regulating hnRNPA1 acetylation
H Zhu, T Li, S Shi, D Chen, W Chen, H Chen - Journal of Experimental & …, 2021 - Springer
Background Emerging evidence indicates that metabolism reprogramming and abnormal
acetylation modification play an important role in lung adenocarcinoma (LUAD) progression …
acetylation modification play an important role in lung adenocarcinoma (LUAD) progression …
Thermodynamic coupling of the tandem RRM domains of hnRNP A1 underlie its pleiotropic RNA binding functions
The functional properties of RNA binding proteins (RBPs) require allosteric regulation
through interdomain communication. Despite the importance of allostery to biological …
through interdomain communication. Despite the importance of allostery to biological …
Filgotinib suppresses HIV-1–driven gene transcription by inhibiting HIV-1 splicing and T cell activation
Despite effective antiretroviral therapy, HIV-1–infected cells continue to produce viral
antigens and induce chronic immune exhaustion. We propose to identify HIV-1–suppressing …
antigens and induce chronic immune exhaustion. We propose to identify HIV-1–suppressing …
Post-translational modifications of hnRNP A1 differentially modulate retroviral IRES-mediated translation initiation
A Barrera, H Ramos, J Vera-Otarola… - Nucleic Acids …, 2020 - academic.oup.com
The full-length mRNAs of the human immunodeficiency virus type-1 (HIV-1), the human T-
cell lymphotropic virus type-1 (HTLV-1), and the mouse mammary tumor virus (MMTV) …
cell lymphotropic virus type-1 (HTLV-1), and the mouse mammary tumor virus (MMTV) …
Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency
Background The generation of over 69 spliced HIV-1 mRNAs from one primary transcript by
alternative RNA splicing emphasizes the central role that RNA processing plays in HIV-1 …
alternative RNA splicing emphasizes the central role that RNA processing plays in HIV-1 …
hnRNPH1-MTR4 complex-mediated regulation of NEAT1v2 stability is critical for IL8 expression
Many long noncoding RNAs (lncRNAs) are localized in the nucleus and play important roles
in various biological processes, including cell proliferation, differentiation and antiviral …
in various biological processes, including cell proliferation, differentiation and antiviral …