Sleep in Alzheimer's disease: a systematic review and meta-analysis of polysomnographic findings

Y Zhang, R Ren, L Yang, H Zhang, Y Shi… - Translational …, 2022 - nature.com
Polysomnography (PSG) studies of sleep changes in Alzheimer's disease (AD) have
reported but not fully established the relationship between sleep disturbances and AD. To …

Targeting amyloid clearance in Alzheimer's disease as a therapeutic strategy

NN Nalivaeva, AJ Turner - British journal of pharmacology, 2019 - Wiley Online Library
Targeting the amyloid‐β (Aβ) peptide cascade has been at the heart of therapeutic
developments in Alzheimer's disease (AD) research for more than 25 years, yet no …

[HTML][HTML] Sleep in Alzheimer's disease–beyond amyloid

JK Holth, TK Patel, DM Holtzman - Neurobiology of sleep and circadian …, 2017 - Elsevier
Sleep disorders are prevalent in Alzheimer's disease (AD) and a major cause of
institutionalization. Like AD pathology, sleep abnormalities can appear years before …

Orexin receptor antagonism: normalizing sleep architecture in old age and disease

JOZJ Kron, RJ Keenan, D Hoyer… - Annual Review of …, 2024 - annualreviews.org
Sleep is essential for human well-being, yet the quality and quantity of sleep reduce as age
advances. Older persons (> 65 years old) are more at risk of disorders accompanied and/or …

Physiological changes in neurodegeneration—mechanistic insights and clinical utility

RM Ahmed, YD Ke, S Vucic, LM Ittner… - Nature Reviews …, 2018 - nature.com
The effects of neurodegenerative syndromes extend beyond cognitive function to involve
key physiological processes, including eating and metabolism, autonomic nervous system …

Altered sleep and EEG power in the P301S Tau transgenic mouse model

JK Holth, TE Mahan, GO Robinson… - Annals of clinical …, 2017 - Wiley Online Library
Objective Sleep disturbances are prevalent in human tauopathies yet despite the
importance of sleep, little is known about its relationship with tau pathology. Here, we …

Eating behavior in frontotemporal dementia: Peripheral hormones vs hypothalamic pathology

RM Ahmed, S Latheef, L Bartley, M Irish, GM Halliday… - Neurology, 2015 - AAN Enterprises
Objective: To contrast the relationships of hormonal eating peptides and hypothalamic
volumes to eating behavior and metabolic changes (body mass index [BMI]) in behavioral …

Sleep disturbances in frontotemporal dementia

SJ McCarter, EK St. Louis, BF Boeve - Current neurology and …, 2016 - Springer
Sleep disorders appear to be frequent comorbidities in patients with frontotemporal
dementia (FTD). Insomnia and excessive daytime sleepiness commonly occur in patients …

Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology

DJ Koss, L Robinson, BD Drever, K Plucińska… - Neurobiology of …, 2016 - Elsevier
Abstract Models of Tau pathology related to frontotemporal dementia (FTD) are essential to
determine underlying neurodegenerative pathologies and resulting tauopathy relevant …

Risk of neurodegenerative diseases in patients with sleep disorders: a nationwide population-based case-control study

W Lin, YK Lin, FC Yang, CH Chung, JM Hu, CH Tsao… - Sleep Medicine, 2023 - Elsevier
Objective Our study aimed to explore the associative relationship between
neurodegenerative diseases and sleep disorders. Patients This 15-year retrospective …