Autoimmunity-associated T cell receptors recognize HLA-B* 27-bound peptides

X Yang, LI Garner, IV Zvyagin, MA Paley, EA Komech… - Nature, 2022 - nature.com
Human leucocyte antigen B* 27 (HLA-B* 27) is strongly associated with inflammatory
diseases of the spine and pelvis (for example, ankylosing spondylitis (AS)) and the eye (that …

Artificial intelligence in uveitis: A comprehensive review

LF Nakayama, LZ Ribeiro, RG Dychiao… - Survey of …, 2023 - Elsevier
Uveitis is a disease complex characterized by intraocular inflammation of the uvea that is an
important cause of blindness and social morbidity. With the dawn of artificial intelligence (AI) …

HLA-B* 27 and ankylosing spondylitis: 50 years of insights and discoveries

MA Khan - Current Rheumatology Reports, 2023 - Springer
Abstract Purpose of Review To commemorate the 50th anniversary of the groundbreaking
discovery of a remarkably strong association between HLA-B* 27 and ankylosing spondylitis …

Development of classification criteria for the uveitides

… of Uveitis Nomenclature (SUN) Working Group - American journal of …, 2021 - Elsevier
Purpose To develop classification criteria for 25 of the most common uveitides. Design
Machine learning using 5,766 cases of 25 uveitides. Methods Cases were collected in an …

Mucosal signatures of pathogenic T cells in HLA-B* 27+ anterior uveitis and axial spondyloarthritis

MA Paley, X Yang, LM Hassman, F Penkava… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
HLA-B* 27 was one of the first HLA alleles associated with an autoimmune disease, ie, axial
spondyloarthritis (axSpA) and acute anterior uveitis (B27AAU), which cause joint and eye …

Keep an eye on the back: spondyloarthritis in patients with acute anterior uveitis

J Rademacher, H Müllner, T Diekhoff… - Arthritis & …, 2023 - Wiley Online Library
Objectives This study was undertaken to analyze the prevalence of spondyloarthritis (SpA)
in patients with acute anterior uveitis (AAU), to identify parameters associated with the …

The role of a multicentre data repository in ocular inflammation: the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS)

SMS Ng, R Low, C Pak, SS Lai, B Lee, P McCluskey… - Eye, 2023 - nature.com
In the current literature, clinical registry cohorts related to ocular inflammation are few and far
between, and there are none involving multi-continental international data. Many existing …

Investigation of the acute pathogenesis of spondyloarthritis/HLA-B27-associated anterior uveitis based on genome-wide association analysis and single-cell …

S Chen, W Huang, Q Wan, Z Tang, X Li, F Zeng… - Journal of Translational …, 2024 - Springer
Abstract Background Patients with spondyloarthritis (SpA)/HLA-B27-associated acute
anterior uveitis (AAU) experience recurring acute flares, which pose significant visual and …

Rheumatologist's perspective on non-infectious uveitis: patterns from tertiary referral rheumatologic clinics in Italy

P Triggianese, M Fatica, F Caso, L Costa… - International Journal of …, 2023 - mdpi.com
Non-infectious uveitis (NIU) can be an early or even the first extra-articular manifestation of
systemic rheumatic diseases, or the first one; thus, rheumatologists are often involved in the …

Evaluation of the SUN classification criteria for Uveitides in an academic Uveitis Practice

LI Mudie, AK Reddy, JL Patnaik, P Pecen, E Kim… - American Journal of …, 2022 - Elsevier
Purpose To evaluate the new Standardization of Uveitis Nomenclature (SUN) classification
criteria for uveitides by applying them to patients in an academic uveitis practice. Design …