Recent advances in the synthesis of indolizines and their π-expanded analogues

B Sadowski, J Klajn, DT Gryko - Organic & Biomolecular Chemistry, 2016 - pubs.rsc.org
Indolizine (pyrrolo [1, 2-a] pyridine) is one of the five isomers of indole and it serves as a
precursor for widespread indolizidine alkaloids. The straightforward synthesis of indolizines …

Recent developments in the cyclization of alkynes and nitrogen compounds for the synthesis of indole derivatives

JSS Neto, G Zeni - Asian Journal of Organic Chemistry, 2021 - Wiley Online Library
This review is intended to highlight the most useful approaches for the synthesis of indole
derivatives (azaindoles, carbazoles, carbolines, indazoles, 3H‐indoles, indolines …

Conversion of Pyridine to Imidazo[1,2-a]pyridines by Copper-Catalyzed Aerobic Dehydrogenative Cyclization with Oxime Esters

H Huang, X Ji, X Tang, M Zhang, X Li, H Jiang - Organic letters, 2013 - ACS Publications
Conversion of Pyridine to Imidazo[1,2-a]pyridines by Copper-Catalyzed Aerobic
Dehydrogenative Cyclization with Oxime Esters | Organic Letters ACS ACS Publications C&EN …

Electrochemically-initiated intramolecular 1, 2-amino oxygenation of alkynes: facile access to formyl-and acyl-substituted indolizines

QL Yang, RC Ma, ZH Li, WW Li, GR Qu… - Organic Chemistry …, 2022 - pubs.rsc.org
Here, an environmentally benign electrooxidative approach to the intramolecular
aminooxygenation of alkynes has been developed. The method allows for the rapid …

Domino Knoevenagel condensation/intramolecular aldol cyclization route to diverse indolizines with densely functionalized pyridine units

M Kim, Y Jung, I Kim - The Journal of Organic Chemistry, 2013 - ACS Publications
A highly efficient [4+ 2] annulation route to polysubstituted indolizines is described
employing a domino Knoevenagel condensation/intramolecular aldol cyclization process as …

When indolizine meets quinoline: Diversity-oriented synthesis of new polyheterocycles and their optical properties

S Park, DI Kwon, J Lee, I Kim - ACS Combinatorial Science, 2015 - ACS Publications
Fluorescence-based technologies play a pivotal role in various biomedical applications.
Here we report an efficient route to a new class of fluorophores, indolizino [3, 2-c] quinolines …

Cycloaromatization approach to polysubstituted indolizines from 2-acetylpyrroles: decoration of the pyridine unit

JH Lee, I Kim - The Journal of Organic Chemistry, 2013 - ACS Publications
A new synthetic route to indolizines with various substituents on the pyridine moiety was
developed by utilizing a facile cycloaromatization of 2-acetylpyrrole derivatives. Without …

Iodine-Mediated Domino Cyclization for One-Pot Synthesis of Indolizine-Fused Chromones via Metal-Free sp3 C–H Functionalization

XJ Zhang, Z Wang, H Zhang, JJ Gao… - The Journal of …, 2021 - ACS Publications
An efficient method for the synthesis of new indolizine-fused chromones has been
accomplished from ethyl (E)-3-(2-acetylphenoxy) acrylates and pyridines in a “one-pot” …

Selective hydrogenation of indolizines: an expeditious approach to derive tetrahydroindolizines and Indolizidines from Morita–Baylis–Hillman adducts

BVM Teodoro, JTM Correia… - The Journal of Organic …, 2015 - ACS Publications
In this study, we describe the hydrogenation of indolizines derived from Morita–Baylis–
Hillman adducts. We demonstrate that functionalized tetrahydroindolizines and indolizidines …

Synthesis, characterization and biological evaluation of anti-cancer indolizine derivatives via inhibiting β-catenin activity and activating p53

SH Moon, Y Jung, SH Kim, I Kim - Bioorganic & Medicinal Chemistry Letters, 2016 - Elsevier
Diversity-oriented construction of new indolizine scaffolds was accomplished by utilizing
domino Knoevenagel condensation/intramolecular aldol cyclization. Biological evaluation …