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Arrayed CRISPRi and quantitative imaging describe the morphotypic landscape of essential mycobacterial genes
Mycobacterium tuberculosis possesses a large number of genes of unknown or predicted
function, undermining fundamental understanding of pathogenicity and drug susceptibility …
function, undermining fundamental understanding of pathogenicity and drug susceptibility …
De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation
Intracellular pathogens including Mycobacterium tuberculosis (Mtb) have evolved with
strategies to uptake amino acids from host cells to fulfil their metabolic requirements …
strategies to uptake amino acids from host cells to fulfil their metabolic requirements …
Characterization of a novel antimicrobial peptide bacipeptin against foodborne pathogens
X Wei, Y Hu, C Sun, S Wu - Journal of Agricultural and Food …, 2024 - ACS Publications
The increasing emergence of multidrug-resistant pathogens and development of
biopreservatives in food industries has increased the demand of novel and safe …
biopreservatives in food industries has increased the demand of novel and safe …
Amino Acid Biosynthesis Inhibitors in Tuberculosis Drug Discovery
M Guida, C Tammaro, M Quaranta, B Salvucci, M Biava… - Pharmaceutics, 2024 - mdpi.com
According to the latest World Health Organization (WHO) report, an estimated 10.6 million
people were diagnosed with tuberculosis (TB) in 2022, and 1.30 million died. A major …
people were diagnosed with tuberculosis (TB) in 2022, and 1.30 million died. A major …
Supplementation of lactobacillus‐fermented rapeseed meal in broiler diet reduces Campylobacter jejuni cecal colonization and limits the l‐tryptophan and l …
F Khattak, S Galgano, NR Pedersen… - Journal of the …, 2024 - Wiley Online Library
BACKGROUND Campylobacter jejuni (C. jejuni), a widely distributed global foodborne
pathogen, primarily linked with contaminated chicken meat, poses a significant health risk …
pathogen, primarily linked with contaminated chicken meat, poses a significant health risk …
Effects of FUdR on gene expression in the C. elegans bacterial diet OP50
Objective Many C. elegans aging studies use the compound 5-fluro-2ʹ-deoxyuridine
(FUdR) to produce a synchronous population of worms. However, the effects of FUdR on the …
(FUdR) to produce a synchronous population of worms. However, the effects of FUdR on the …
Characterization of a triazole scaffold compound as an inhibitor of Mycobacterium tuberculosis imidazoleglycerol‐phosphate dehydratase
D Kumar, B Jha, I Bhatia, A Ashraf… - Proteins: Structure …, 2022 - Wiley Online Library
Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis (TB), employs
ten enzymes including imidazoleglycerol‐phosphate dehydratase (IGPD) for de novo …
ten enzymes including imidazoleglycerol‐phosphate dehydratase (IGPD) for de novo …
A whole genome bioinformatic approach to determine potential latent phase specific targets in Mycobacterium tuberculosis
Current Tuberculosis treatment is long and expensive, faces the increasing burden of
MDR/XDR strains and lack of effective treatment against latent form, resulting in an urgent …
MDR/XDR strains and lack of effective treatment against latent form, resulting in an urgent …
Rv2231c, a unique histidinol phosphate aminotransferase from Mycobacterium tuberculosis, supports virulence by inhibiting host-directed defense
Nitrogen metabolism of M. tuberculosis is critical for its survival in infected host cells. M.
tuberculosis has evolved sophisticated strategies to switch between de novo synthesis and …
tuberculosis has evolved sophisticated strategies to switch between de novo synthesis and …
[HTML][HTML] Role of a high centrality residue in protein dynamics and thermal stability
Abstract Centralities determined from Residue Interaction Networks (RIN) in proteins have
been used to predict aspects of their structure and dynamics. Here, we correlate the …
been used to predict aspects of their structure and dynamics. Here, we correlate the …