Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

The emergence of multidrug‐resistant bacteria has placed a strain on health care systems
and highlighted the need for new classes of antibiotics. Bacterial lipopeptides are secondary …

The global public health threat of antimicrobial resistance has led the scientific community to
highly engage into research on alternative strategies to the traditional small molecule …

Tridecaptin A1 (TriA1) is a nonribosomal lipopeptide with selective antimicrobial activity
against Gram-negative bacteria. Here we show that TriA1 exerts its bactericidal effect by …

With increasing rates of resistance toward commonly used antibiotics, especially among
Gram-negative bacteria, there is renewed interested in polymyxins. Polymyxins are …

Peptides can be converted to highly active compounds by introducing appropriate
substituents on the suitable amino acid residue. Although modifiable residues in peptides …

Since Fleming's discovery of penicillin nearly a century ago, a bounty of natural product
antibiotics have been discovered, many of which continue to be of clinical importance today …

Infectious diseases impose serious public health burdens and often have devastating
consequences. The cyclic lipopeptides elaborated by bacteria Bacillus, Paenibacillus …

ABSTRACT The World Health Organization has categorized the Gram-negative superbugs,
which are inherently impervious to many antibiotics, as critical priority pathogens due to the …

Brevicidine and laterocidine are two recently discovered lipopeptide antibiotics with
promising antibacterial activity. Possessing a macrocyclic core, multiple positive charges …