We review recent evidence showing that cell and tissue dynamics are governed by
mesoscale physical principles. These principles can be understood in terms of simple state …

Collective cell motility is crucial to many biological processes including morphogenesis,
wound healing, and cancer invasion. Recently, the biology and biophysics communities …

Tissue, cell, and nucleus morphology change during tumor progression. In 2D confluent cell
cultures, different tissue states, such as fluid (unjammed) and solid (jammed), are correlated …

Intestinal organoids capture essential features of the intestinal epithelium such as crypt
folding, cellular compartmentalization and collective movements. Each of these processes …

Embryo morphogenesis is impacted by dynamic changes in tissue material properties,
which have been proposed to occur via processes akin to phase transitions (PTs). Here, we …

Epithelial cell monolayers show remarkable displacement and velocity correlations over
distances of ten or more cell sizes that are reminiscent of supercooled liquids and active …

Tissue morphogenesis in multicellular organisms is brought about by spatiotemporal
coordination of mechanical and chemical signals. Extensive work on how mechanical forces …

In development, lineage segregation is coordinated in time and space. An important
example is the mammalian inner cell mass, in which the primitive endoderm (PrE, founder of …

Although rigidity and jamming transitions have been widely studied in physics and material
science, their importance in a number of biological processes, including embryo …

We present an approach to understand geometric-incompatibility–induced rigidity in
underconstrained materials, including subisostatic 2D spring networks and 2D and 3D …