[HTML][HTML] Overcoming Cancer Multi-drug Resistance (MDR): Reasons, mechanisms, nanotherapeutic solutions, and challenges

C Duan, M Yu, J Xu, BY Li, Y Zhao… - Biomedicine & …, 2023 - Elsevier
Multi-drug resistance (MDR) in cancer cells, either intrinsic or acquired through various
mechanisms, significantly hinders the therapeutic efficacy of drugs. Typically, the reduced …

Current understanding of passive and active targeting nanomedicines to enhance tumor accumulation

Z Chen, RK Kankala, L Long, S **e, AZ Chen… - Coordination Chemistry …, 2023 - Elsevier
In recent years, tremendous advancements in nanomedicine have resulted in the rapid
development of various nanoformulations, especially the treatment of solid tumors. Despite …

Nanoparticles Mediated the Diagnosis and Therapy of Glioblastoma: Bypass or Cross the Blood–Brain Barrier

X Song, H Qian, Y Yu - Small, 2023 - Wiley Online Library
Glioblastoma is one of the most aggressive central nervous system malignancies with high
morbidity and mortality. Current clinical approaches, including surgical resection …

An efficacy and mechanism driven study on the impact of Hypoxia on lipid nanoparticle mediated mRNA delivery

Y Ma, OS Fenton - Journal of the American Chemical Society, 2023 - ACS Publications
Hypoxia is a common hallmark of human disease that is characterized by abnormally low
oxygen levels in the body. While the effects of hypoxia on many small molecule-based drugs …

Cellular Trafficking of Nanotechnology‐Mediated mRNA Delivery

P Huang, H Deng, C Wang, Y Zhou… - Advanced …, 2024 - Wiley Online Library
Messenger RNA (mRNA)‐based therapy has emerged as a powerful, safe, and rapidly
scalable therapeutic approach that involves technologies for both mRNA itself and the …

Strategies for the development of stimuli-responsive small molecule prodrugs for cancer treatment

Y Tu, J Gong, J Mou, H Jiang, H Zhao… - Frontiers in …, 2024 - frontiersin.org
Approved anticancer drugs typically face challenges due to their narrow therapeutic window,
primarily because of high systemic toxicity and limited selectivity for tumors. Prodrugs are …

Ultrasensitive DNA Origami Plasmon Sensor for Accurate Detection in Circulating Tumor DNAs

Z Chen, C Meng, X Wang, J Chen… - Laser & Photonics …, 2024 - Wiley Online Library
Early lung cancer screening by computed tomography is hampered by pulmonary nodules
caused by massive COVID‐19 infections, necessitating an ultrasensitive approach for the …

[HTML][HTML] Polyamidoamine Dendrimers: Brain-Targeted Drug Delivery Systems in Glioma Therapy

X Yan, Q Chen - Polymers, 2024 - mdpi.com
Glioma is the most common primary intracranial tumor, which is formed by the malignant
transformation of glial cells in the brain and spinal cord. It has the characteristics of high …

[HTML][HTML] Elucidating genetic and molecular basis of altered higher-order brain structure-function coupling in major depressive disorder

H Long, Z Chen, X Xu, Q Zhou, Z Fang, M Lv, XH Yang… - NeuroImage, 2024 - Elsevier
Previous studies have shown that major depressive disorder (MDD) patients exhibit
structural and functional impairments, but few studies have investigated changes in higher …

Ternary Cu2MX4 (CMX)-based nanoarchitectonics: Chemistry, synthesis, and biomedical applications

C Duan, M Yu, Y Zhao, X Chen, RK Kankala - Coordination Chemistry …, 2024 - Elsevier
Owing to their elemental abundance and unique bandgap, ternary transition metal
chalcogenides (TMCs) have recently attracted significant attention from researchers. Among …