Autonomic manifestations of epilepsy: emerging pathways to sudden death?

RD Thijs, P Ryvlin, R Surges - Nature Reviews Neurology, 2021 - nature.com
Epileptic networks are intimately connected with the autonomic nervous system, as
exemplified by a plethora of ictal (during a seizure) autonomic manifestations, including …

Serotonin and sudden unexpected death in epilepsy

AN Petrucci, KG Joyal, BS Purnell, GF Buchanan - Experimental neurology, 2020 - Elsevier
Epilepsy is a highly prevalent disease characterized by recurrent, spontaneous seizures.
Approximately one-third of epilepsy patients will not achieve seizure freedom with medical …

Seizure semiology: ILAE glossary of terms and their significance

S Beniczky, WO Tatum, H Blumenfeld, H Stefan… - Epileptic …, 2022 - stm.cairn.info
2. Tatum W, Rubboli G, Kaplan P, Mirsatari S, Radhakrishnan K, Gloss D, et al. Clinical utility
of EEG in diagnosing and monitoring epilepsy in adults. Clin Neurophysiol 2018; 129 (5) …

Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP)

L Vilella, N Lacuey, JP Hampson, MRS Rani… - Neurology, 2019 - AAN Enterprises
Objective To characterize peri-ictal apnea and postictal asystole in generalized convulsive
seizures (GCS) of intractable epilepsy. Methods This was a prospective, multicenter epilepsy …

A unified hypothesis of SUDEP: Seizure‐induced respiratory depression induced by adenosine may lead to SUDEP but can be prevented by autoresuscitation and …

CL Faingold, HJ Feng - Epilepsia, 2023 - Wiley Online Library
Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in people with
epilepsy (PWE). Postictal apnea leading to cardiac arrest is the most common sequence of …

[HTML][HTML] Sudden unexpected death in epilepsy: The neuro-cardio-respiratory connection

TA Manolis, AA Manolis, H Melita, AS Manolis - Seizure, 2019 - Elsevier
Sudden unexpected death in epilepsy (SUDEP) is the major cause of epilepsy-related
premature mortality which targets preferentially younger people. Its etiology remains …

Risks and predictive biomarkers of sudden unexpected death in epilepsy patient

P Ryvlin, S Rheims, SD Lhatoo - Current opinion in neurology, 2019 - journals.lww.com
Risks and predictive biomarkers of sudden unexpected death i... : Current Opinion in
Neurology Risks and predictive biomarkers of sudden unexpected death in epilepsy patient …

[HTML][HTML] Failure to breathe persists without air hunger or alarm following amygdala seizures

GIS Harmata, AE Rhone, CK Kovach, S Kumar… - JCI insight, 2023 - ncbi.nlm.nih.gov
Postictal apnea is thought to be a major cause of sudden unexpected death in epilepsy
(SUDEP). However, the mechanisms underlying postictal apnea are unknown. To …

Incidence, recurrence, and risk factors for peri-ictal central apnea and sudden unexpected death in epilepsy

L Vilella, N Lacuey, JP Hampson, MRS Rani… - Frontiers in …, 2019 - frontiersin.org
Introduction: Peri-ictal breathing dysfunction was proposed as a potential mechanism for
SUDEP. We examined the incidence and risk factors for both ictal (ICA) and post-convulsive …

The good, the bad, and the deadly: adenosinergic mechanisms underlying sudden unexpected death in epilepsy

B Purnell, M Murugan, R Jani, D Boison - Frontiers in neuroscience, 2021 - frontiersin.org
Adenosine is an inhibitory modulator of neuronal excitability. Neuronal activity results in
increased adenosine release, thereby constraining excessive excitation. The exceptionally …