Genetically modified immune responses to infections and self-antigens initiate most forms of
GN by generating pathogen-and danger-associated molecular patterns that stimulate Toll …

Lessons from an animal model that faithfully resembles human membranous nephropathy
(MN) have informed our understanding of the pathogenesis of this organ-specific …

Background Idiopathic membranous nephropathy, a common form of the nephrotic
syndrome, is an antibody-mediated autoimmune glomerular disease. Serologic diagnosis …

The M-type phospholipase A2 receptor (PLA2R) is a target autoantigen in adult idiopathic
membranous nephropathy (MN), but the prevalence of autoantibodies against PLA2R is …

A direct causal association between hepatitis B virus (HBV) infection and the development of
nephropathy remains controversial. Epidemiological studies have shown that chronic …

We examined the role of antigenic electrical charge as a determinant of glomerular immune
complex localization in the rabbit. Serum sickness nephritis was induced in groups of New …

Insights from experimental studies have been recently translated into substantial advances
in understanding the pathogenesis of human membranous nephropathy (MN). These …

The only established role for complement in mediating immunologic renal disease involves
elaboration of leukochemotactic factors and neutrophil-dependent glomerular injury. In the …

The pathogenesis of membranous nephropathy (MN) involves in situ formation of
subepithelial immune deposits that produce glomerular injury by damaging and/or activating …

Membranous nephropathy (MN) is a renal-limited non-inflammatory autoimmune disease in
the glomerulus, which is the second or third main cause of end-stage kidney diseases in …