Quinolones are broad-spectrum synthetic antibacterial drugs first obtained during the
synthesis of chloroquine. Nalidixic acid, the prototype of quinolones, first became available …

In current scenario, various heterocycles have come up exhibiting crucial role in various
medicinal agents which are valuable for mankind. Out of diverse range of heterocycle …

Recently, we reported small-molecule chalcones as a novel class of HIV-1 integrase (IN)
inhibitors. The most potent compound showed an IC50 value of 2μM for both IN-mediated …

A set of 4-quinolone-3-carboxylic acids bearing different substituents on the condensed
benzene ring was designed and synthesized as potential HIV-1 integrase inhibitors …

Palladium-Catalyzed Tandem Amination Reaction for the Synthesis of 4-Quinolones | Organic
Letters ACS ACS Publications C&EN CAS Find my institution Log In Organic Letters ACS …

Quinolones are among the most common frameworks present in the bioactive molecules
and hence represent an attractive starting point for the design of combinatorial libraries …

Protein flexibility plays a major role in biomolecular recognition. In many cases, it is not
obvious how molecular structure will change upon association with other molecules. In …

Background Two inhibitors of the HIV-1 integrase enzyme (INIs) are in late stage clinical
development. To date, approximately 42 mutations within the HIV-1 integrase (IN) gene …

In connection with a project aimed at preparing new series of diketotetrazoles (see
compound 1 in Scheme 1, for which two representative tautomers are shown) and …

Reverse transcriptase (RT) plays an indispensable role in the replication of human
immunodeficiency virus (HIV) through its associated polymerase and ribonuclease H …