Flipper probes have been introduced as small molecule fluorophores to image physical
forces, that is, membrane tension in living systems. Their emergence over one decade is …

Bioluminescence has long been used to image biological processes in vivo. This technology
features luciferase enzymes and luciferin small molecules that produce visible light …

Mechanical forces drive critical cellular processes that are reflected in mechanical
phenotypes, or mechanotypes, of cells and their microenvironment. We present here …

Dystrophin is an essential muscle protein that contributes to cell membrane stability by
mechanically linking the actin cytoskeleton to the extracellular matrix via an adhesion …

HydroFlippers are introduced as the first fluorescent membrane tension probes that report
simultaneously on membrane compression and hydration. The probe design is centered …

Integrins are transmembrane receptors associated with adhesion and migration and are
often highly differentially expressed receptors amongst natural killer cell subsets in …

Linkers play critical roles in the construction of synthetic protein switches and sensors as
they functionally couple a receptor with an actuator. With an increasing number of molecular …

Fluorescent flipper probes have been introduced recently to image membrane tension in live
cells, and strategies to target these probes to specific membranes are emerging. In this …

Bioluminescent sensor proteins have recently gained popularity in both basic research and
point-of-care diagnostics. Sensor proteins based on intramolecular complementation of split …

The occurrence and development of many diseases are accompanied and sometimes
dictated by the destruction of biomechanical homeostasis. For instance, cancer cells and …