Clozapine is the gold standard for treatment-resistant schizophrenia. Serious and even life-
threatening adverse effects, mostly granulocytopenia, myocarditis, and constipation, are of …

Antipsychotics are the cornerstone in the management of psychotic disorders and
schizophrenia. They are effective agents but also have a wide range of side effects. In the …

Therapeutic drug monitoring of plasma clozapine and of its principal plasma metabolite N-
desmethylclozapine (norclozapine)(predose or “trough” sample) can help in monitoring …

Constipation is a known side effect of psychotropics that possess high affinity for muscarinic
cholinergic receptors. In severe cases, constipation progresses to ileus and bowel ischemia …

Objective The haematological and cardiac complications of clozapine have been well
documented. Recent evidence from pharmacovigilance databases suggests that …

AIM: To highlight some problems that may occur when investigating clozapine-associated
deaths including (i) that death may be related to gastrointestinal hypomotility and (ii) that …

Fulminant hepatic failure (FHF) refers to the rapid development of severe acute liver injury
with impaired synthetic function and encephalopathy in a person who previously had a …

Cardiac autonomic dysfunction has been reported in patients suffering from schizophrenia.
The aim of the present study was to evaluate gastric electrical activity in unmedicated …

OBJECTIVE To report on a patient who was successfully rechallenged with clozapine after
perforation of the large intestine and pulmonary embolism postoperatively, and provide a …

Clozapine is the preferred antipsychotic used for the treatment of resistant schizophrenia
with suicidal ideation. The drug is started at a low dose and gradually increased to a target …