GABAA (γ-aminobutyric acid type A) receptors mediate most of the'fast'synaptic inhibition in
the mammalian brain and are targeted by many clinically important drugs. Certain naturally …

The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

Cell-surface receptors are the targets for more than 60% of current drugs. Traditionally,
optimizing the interaction of lead molecules with the binding site for the endogenous agonist …

The GABA‐modulating and GABA‐mimetic activities of the monoterpenoid thymol were
explored on human GABAA and Drosophila melanogaster homomeric RDLac GABA …

Background Increasing evidence suggests that multiple or long-time exposure to general
anaesthesia (GA) could be detrimental to cognitive development in young subjects and …

We investigated the role of regionally discrete GABA (γ-aminobutyric acid) receptors in the
sedative response to pharmacological agents that act on GABAA receptors (muscimol …

Certain metabolites of progesterone and deoxycorticosterone are established as potent and
selective positive allosteric modulators of the γ-aminobutyric acid type A (GABAA) receptor …

Among hypnotic agents that enhance GABAA receptor function, etomidate is unusual
because it is selective for β2/β3 compared with β1 subunit-containing GABAA receptors …

Two-pore-domain K+(K 2P) channels are a diverse and highly regulated superfamily of
channels that are thought to provide baseline regulation of membrane excitability. Of these …

The mechanisms of general anesthesia in the central nervous system are finally yielding to
molecular examination. As a result of research during the past several decades, a group of …