G protein–coupled receptor kinases (GRKs) constitute a family of six mammalian
serine/threonine protein kinases that phosphorylate agonist-bound, or activated, G protein …

▪ Abstract Platelet-activating factor (PAF) is a phospholipid with potent, diverse physiological
actions, particularly as a mediator of inflammation. The synthesis, transport, and degradation …

One of the assumptions of the mobile receptor hypothesis as it relates to G protein-coupled
receptors is that the stoichiometry of receptor, G protein, and effector is 1: 1: 1 (Bourne, HR …

The platelet-activating factor signaling system and its regu... : Critical Care Medicine The
platelet-activating factor signaling system and its regulators in syndromes of inflammation and …

Dimerization of G-protein-coupled receptors has been increasingly noted in the regulation of
their biological activity. However, its involvement in agonist-induced receptor internalization …

Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a
biologically active phospholipid mediator. Although PAF was initially recognized for its …

Human LL-37 is a multifunctional antimicrobial peptide that promotes inflammation,
angiogenesis, wound healing, and tumor metastasis. Most effects of LL-37 are mediated via …

Cysteine-rich domains (Cys-domains) are∼ 50–amino acid–long protein domains that
complex two zinc ions and include a consensus sequence with six cysteine and two …

G-protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
receptors in the human genome that respond to a plethora of signals, including …

Members of the chemokine receptor family CCR5 and CXCR4 have recently been shown to
be involved in the entry of human immunodeficiency virus (HIV) into target cells. Here, we …