Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …

Palmitic acid (PA) has been for long time negatively depicted for its putative detrimental
health effects, shadowing its multiple crucial physiological activities. PA is the most common …

The global prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically
increased in parallel with the epidemic of obesity. Controversy has emerged around dietary …

Background & Aims There have been few studies of the role of de novo lipogenesis in the
development of nonalcoholic fatty liver disease (NAFLD). We used isotope analyses to …

The primary genetic, environmental, and metabolic factors responsible for causing insulin
resistance and pancreatic β-cell failure and the precise sequence of events leading to the …

The current study was undertaken to investigate fatty acid metabolism by skeletal muscle to
examine potential mechanisms that could lead to increased muscle triglyceride in obesity …

Hepatic de novo lipogenesis (DNL) is the biochemical process of synthesising fatty acids
from acetyl‐CoA subunits that are produced from a number of different pathways within the …

Nonalcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide, and is
commonly associated with the metabolic syndrome. Secular trends in the prevalence of …

Background & aims Excessive fructose intake is associated with increased de novo
lipogenesis, blood triglycerides, and hepatic insulin resistance. We aimed to determine …

Objective To determine the effects of diets varying in carbohydrate to fat ratio on total energy
expenditure. Design Randomized trial. Setting Multicenter collaboration at US two sites …