The impact of the gut microbiome on extra-intestinal autoimmune diseases
E Miyauchi, C Shimokawa, A Steimle… - Nature Reviews …, 2023 - nature.com
The prevalence of autoimmune diseases (ADs) worldwide has rapidly increased over the
past few decades. Thus, in addition to the classical risk factors for ADs, such as genetic …
past few decades. Thus, in addition to the classical risk factors for ADs, such as genetic …
Cytokine regulation and function in T cells
C Dong - Annual review of immunology, 2021 - annualreviews.org
T lymphocytes, the major effector cells in cellular immunity, produce cytokines in immune
responses to mediate inflammation and regulate other types of immune cells. Work in the …
responses to mediate inflammation and regulate other types of immune cells. Work in the …
TH17 cell heterogeneity and its role in tissue inflammation
Since their discovery almost two decades ago, interleukin-17-producing CD4+ T cells (TH17
cells) have been implicated in the pathogenesis of multiple autoimmune and inflammatory …
cells) have been implicated in the pathogenesis of multiple autoimmune and inflammatory …
Gut microbiota interact with the brain through systemic chronic inflammation: implications on neuroinflammation, neurodegeneration, and aging
Y Mou, Y Du, L Zhou, J Yue, X Hu, Y Liu… - Frontiers in …, 2022 - frontiersin.org
It has been noticed in recent years that the unfavorable effects of the gut microbiota could
exhaust host vigor and life, yet knowledge and theory are just beginning to be established …
exhaust host vigor and life, yet knowledge and theory are just beginning to be established …
Gut-microbiota-derived metabolites maintain gut and systemic immune homeostasis
J Wang, N Zhu, X Su, Y Gao, R Yang - Cells, 2023 - mdpi.com
The gut microbiota, including bacteria, archaea, fungi, viruses and phages, inhabits the
gastrointestinal tract. This commensal microbiota can contribute to the regulation of host …
gastrointestinal tract. This commensal microbiota can contribute to the regulation of host …
Control of immunity by the microbiota
The immune system has coevolved with extensive microbial communities living on barrier
sites that are collectively known as the microbiota. It is increasingly clear that microbial …
sites that are collectively known as the microbiota. It is increasingly clear that microbial …
Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring
INTRODUCTION One fundamental property of the immune system is its ability to develop
memory of previous encounters, resulting in enhanced responsiveness to subsequent …
memory of previous encounters, resulting in enhanced responsiveness to subsequent …
Conditioning of the immune system by the microbiome
DB Graham, RJ Xavier - Trends in Immunology, 2023 - cell.com
The human intestinal microbiome has coevolved with its host to establish a stable
homeostatic relationship with hallmark features of mutualistic symbioses, yet the mechanistic …
homeostatic relationship with hallmark features of mutualistic symbioses, yet the mechanistic …
Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation
J Zhang, Q Yu, D Jiang, K Yu, W Yu, Z Chi… - Science …, 2022 - science.org
Goblet cells and their main secretory product, mucus, play crucial roles in orchestrating the
colonic host-microbe interactions that help maintain gut homeostasis. However, the precise …
colonic host-microbe interactions that help maintain gut homeostasis. However, the precise …
New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology
MD Giraldez, D Carneros, C Garbers… - Nature reviews …, 2021 - nature.com
IL-6 family cytokines are defined by the common use of the signal-transducing receptor
chain glycoprotein 130 (gp130). Increasing evidence indicates that these cytokines are …
chain glycoprotein 130 (gp130). Increasing evidence indicates that these cytokines are …