Roughly one quarter of all genes code for integral membrane proteins that are inserted into
the plasma membrane of prokaryotes or the endoplasmic reticulum membrane of …

Gram-negative bacteria and their complex cell envelope, which comprises an outer
membrane and an inner membrane, are an important and attractive system for studying the …

The outer membrane structure is common in Gram-negative bacteria, mitochondria and
chloroplasts, and contains outer membrane β-barrel proteins (OMPs) that are essential …

Recent studies applying advanced imaging techniques are changing the way we
understand bacterial cell surfaces, bringing new knowledge on everything from single-cell …

A defining step in the biogenesis of a membrane protein is the insertion of its hydrophobic
transmembrane helices into the lipid bilayer. The nine-subunit endoplasmic reticulum (ER) …

Increasing antibiotic resistance urges for new technologies for studying microbes and
antimicrobial mechanism of action. We adapted thermal proteome profiling (TPP) to probe …

The folding and insertion of integral β-barrel membrane proteins into the outer membrane of
Gram-negative bacteria is required for viability and bacterial pathogenesis. Unfortunately …

Transmembrane β barrel proteins are folded into the outer membrane (OM) of Gram-
negative bacteria by the β barrel assembly machinery (BAM) via a poorly understood …

The type 9 secretion system (T9SS) is the protein export pathway of bacteria of the Gram-
negative Fibrobacteres–Chlorobi–Bacteroidetes superphylum and is an essential …

The integration of β-barrel proteins into the bacterial outer membrane (OM) is catalysed by
the β-barrel assembly machinery (BAM). The central BAM subunit (BamA) itself contains a β …