Cytokine-mediated communication: a quantitative appraisal of immune complexity

G Altan-Bonnet, R Mukherjee - Nature Reviews Immunology, 2019 - nature.com
Intercellular communication mediated by cytokines is the main mechanism by which cells of
the immune system talk to each other. Many aspects of cytokine signalling in the immune …

Better together: engineering and application of microbial symbioses

SG Hays, WG Patrick, M Ziesack, N Oxman… - Current opinion in …, 2015 - Elsevier
Highlights•Microbial communities are naturally abundant.•Natural symbioses exhibit
increased robustness and metabolic capabilities.•Technological advances in environmental …

Optogenetic regulation of engineered cellular metabolism for microbial chemical production

EM Zhao, Y Zhang, J Mehl, H Park, MA Lalwani… - Nature, 2018 - nature.com
The optimization of engineered metabolic pathways requires careful control over the levels
and timing of metabolic enzyme expression,,,. Optogenetic tools are ideal for achieving such …

[HTML][HTML] Circuit design features of a stable two-cell system

X Zhou, RA Franklin, M Adler, JB Jacox, W Bailis… - Cell, 2018 - cell.com
Cell communication within tissues is mediated by multiple paracrine signals including
growth factors, which control cell survival and proliferation. Cells and the growth factors they …

DNA-based communication in populations of synthetic protocells

A Joesaar, S Yang, B Bögels, A van der Linden… - Nature …, 2019 - nature.com
Develo** molecular communication platforms based on orthogonal communication
channels is a crucial step towards engineering artificial multicellular systems. Here, we …

Genetic circuit design automation for yeast

Y Chen, S Zhang, EM Young, TS Jones… - Nature …, 2020 - nature.com
Cells can be programmed to monitor and react to their environment using genetic circuits.
Design automation software maps a desired circuit function to a DNA sequence, a process …

Patiency is not a virtue: the design of intelligent systems and systems of ethics

JJ Bryson - Ethics and Information Technology, 2018 - Springer
The question of whether AI systems such as robots can or should be afforded moral agency
or patiency is not one amenable either to discovery or simple reasoning, because we as …

De novo design of an intercellular signaling toolbox for multi-channel cell–cell communication and biological computation

P Du, H Zhao, H Zhang, R Wang, J Huang… - Nature …, 2020 - nature.com
Intercellular signaling is indispensable for single cells to form complex biological structures,
such as biofilms, tissues and organs. The genetic tools available for engineering …

Directing cellular information flow via CRISPR signal conductors

Y Liu, Y Zhan, Z Chen, A He, J Li, H Wu, L Liu… - Nature …, 2016 - nature.com
The complex phenotypes of eukaryotic cells are controlled by decision-making circuits and
signaling pathways. A key obstacle to implementing artificial connections in signaling …

[HTML][HTML] Organ-level quorum sensing directs regeneration in hair stem cell populations

CC Chen, L Wang, MV Plikus, TX Jiang, PJ Murray… - Cell, 2015 - cell.com
Coordinated organ behavior is crucial for an effective response to environmental stimuli. By
studying regeneration of hair follicles in response to patterned hair plucking, we …