Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …

Carriers of germline mutations in the TP53 gene, encoding the cell-cycle regulator and
tumour suppressor p53, have a markedly increased risk of cancer-related morbidity and …

Patients with Beckwith–Wiedemann syndrome (BWS) have an increased risk to develop
cancer in childhood, especially Wilms tumor and hepatoblastoma. The risk varies depending …

Background The National Wilms Tumor Study (NWTS) approach to treating stage III
favorable-histology Wilms tumor (FHWT) is Regimen DD4A (vincristine, dactinomycin, and …

Survival for patients with Wilms' tumor when considered as a whole, once less than 30%, is
currently greater than 90%, with this dramatic improvement being due, in part, to the …

Most children with tumors will require one or more surgical interventions as part of the care
and treatment, including making a diagnosis, obtaining adequate venous access …

Summary Chu A, Heck JE, Ribeiro KB, Brennan P, Boffetta P, Buffler P, Hung RJ. Wilms'
tumour: a systematic review of risk factors and meta‐analysis. Paediatric and Perinatal …

Although tremendous progress has been made in treating childhood cancer, it is still one of
the leading causes of death in children worldwide. Because cancer symptoms overlap with …

There are considerable differences in tumour biology between adult and paediatric cancers.
The existence of cancer initiating cells/cancer stem cells (CIC/CSC) in paediatric solid …

PURPOSE: To determine the prognosis of children with stage II and III of low or intermediate
risk histology (SIOP classification) in unilateral localised Wilms tumour (WT) after …