Mitochondria carry their own genetic information encoding for a subset of protein-coding
genes and translational machinery essential for cellular respiration and metabolism. Despite …

Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad of vital
functions across diverse cellular processes. Dysfunctions within mitochondria serve as …

Clonal expansion of antigen‐specific lymphocytes is the fundamental mechanism enabling
potent adaptive immune responses and the generation of immune memory. Accompanied …

Mutations of mitochondrial (mt) DNA are a major cause of morbidity and mortality in humans,
accounting for approximately two thirds of diagnosed mitochondrial disease. However …

Multiplexing across donors has emerged as a popular strategy to increase throughput,
reduce costs, overcome technical batch effects, and improve doublet detection in single-cell …

Single cell sequencing technologies have become a fixture in the molecular profiling of cells
due to their ease, flexibility, and commercial availability. In particular, partitioning individual …

As a chronic autoimmune disease with complex aetiology, rheumatoid arthritis (RA) has
been demonstrated to be associated with mitochondrial dysfunction since mitochondrial …

Mitochondria, the cellular powerhouses, possess their own unique genetic system, including
replication, transcription, and translation. Studying these processes is crucial for …

T cells have been shown to maintain a lower percentage (heteroplasmy) of the pathogenic
m. 3243A> G variant (MT‐TL1, associated with maternally inherited diabetes and deafness …

Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by
memory impairment and cognitive dysfunction, which eventually leads to the disability and …