Lysosome integrity is essential for cell viability, and lesions in lysosome membranes are
repaired by the ESCRT machinery. Here, we describe an additional mechanism for …

The endolysosomal system specializes in degrading cellular components and is crucial to
maintaining homeostasis and adapting rapidly to metabolic and environmental cues. Cells …

Lysosomes are crucial organelles essential for various cellular processes, and any damage
to them can severely compromise cell viability. This study uncovers a previously …

Conjugated oligoelectrolytes (COEs) are lipid bilayer spanning optical reporters that hold
promise for delineating spatiotemporal changes in subcellular compartments. However, their …

Lysosomes are pivotal in cellular functions and disease, influencing cancer progression and
therapy resistance with Acid Sphingomyelinase (ASM) governing their membrane integrity …

Lysosome integrity is essential for cell viability, and lesions in lysosome membranes are
repaired by the ESCRT machinery. Here we describe an additional mechanism for lysosome …

The self-templating nature of prions plays a central role in prion pathogenesis and is
associated with infectivity and transmissibility. Since propagation of proteopathic seeds has …