The key pathological hallmarks—extracellular plaques and intracellular neurofibrillary
tangles (NFT)—described by Alois Alzheimer in his seminal 1907 article are still central to …

Alois Alzheimer first pointed out that the disease which would later bear his name has a
distinct and recognizable neuropathological substrate. Since then, much has been added to …

To learn about the carboxy-terminal extent of amyloid g-protein (Ag) composition of senile
plaques (SPs) in the brain affected with Alzheimer's disease (AD), we employed two end …

CEREBRAL deposition of the β-amyloid peptide (Aβ) is an invariant feature of Alzheimer's
disease. Since the original isola-tion and characterization of αβ (ref. 1) and the subsequent …

Normal processing of the amyloid β protein precursor (βAPP) results in secretion of a
soluble 4-kilodalton protein essentially identical to the amyloid β protein (Aβ) that forms …

Elimination of amyloid-β peptide (Aβ) from the brain is poorly understood. After intracerebral
microinjections in young mice, 125I-Aβ1-40 was rapidly removed from the brain (t 1/2≤ 25 …

An amyloid protein that precipitates in the cerebral vessel walls of Dutch patients with
hereditary cerebral hemorrhage with amyloidosis is similar to the amyloid protein in vessel …

Zinc is one of the most abundant nutritionally essential elements in the human body. It is
found in all body tissues with 85% of the whole body zinc in muscle and bone, 11% in the …

The 4-kilodalton (39 to 43 amino acids) amyloid β protein (βAP), which is deposited as
amyloid in the brains of patients with Alzheimer's disease, is derived from a large protein, the …

The amyloid A4 or beta peptide is a major component of extracellular amyloid deposits that
are a characteristic feature of Alzheimer's disease. We synthesized a series of peptide …