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[HTML][HTML] Levodopa-induced dyskinesia in Parkinson's disease: pathogenesis and emerging treatment strategies
The most commonly used treatment for Parkinson's disease (PD) is levodopa, prescribed in
conjunction with carbidopa. Virtually all patients with PD undergo dopamine replacement …
conjunction with carbidopa. Virtually all patients with PD undergo dopamine replacement …
Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease
People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor
deficits that are resistant to currently available therapies. To alleviate these deficits, we …
deficits that are resistant to currently available therapies. To alleviate these deficits, we …
Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update
Dopaminergic medications used in the treatment of patients with Parkinson's disease are
associated with motor and non-motor behavioural side-effects, such as dyskinesias and …
associated with motor and non-motor behavioural side-effects, such as dyskinesias and …
G protein–coupled receptor oligomerization revisited: functional and pharmacological perspectives
Most evidence indicates that, as for family CG protein–coupled receptors (GPCRs), family A
GPCRs form homo-and heteromers. Homodimers seem to be a predominant species, with …
GPCRs form homo-and heteromers. Homodimers seem to be a predominant species, with …
Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease
S Duty, P Jenner - British journal of pharmacology, 2011 - Wiley Online Library
Animal models of Parkinson's disease (PD) have proved highly effective in the discovery of
novel treatments for motor symptoms of PD and in the search for clues to the underlying …
novel treatments for motor symptoms of PD and in the search for clues to the underlying …
The scientific and clinical basis for the treatment of Parkinson disease (2009)
CW Olanow, MB Stern, K Sethi - Neurology, 2009 - neurology.org
Parkinson disease (PD) is an age-related neurodegenerative disorder that affects as many
as 1–2% of persons aged 60 years and older. With the aging of the population, the …
as 1–2% of persons aged 60 years and older. With the aging of the population, the …
G protein-coupled receptor kinases: more than just kinases and not only for GPCRs
G protein-coupled receptor (GPCR) kinases (GRKs) are best known for their role in
homologous desensitization of GPCRs. GRKs phosphorylate activated receptors and …
homologous desensitization of GPCRs. GRKs phosphorylate activated receptors and …
Wearable sweat band for noninvasive levodopa monitoring
Levodopa is the standard medication clinically prescribed to patients afflicted with
Parkinson's disease. In particular, the monitoring and optimization of levodopa dosage are …
Parkinson's disease. In particular, the monitoring and optimization of levodopa dosage are …
The dopamine D3 receptor, a quarter century later
This review updates the existing knowledge suggesting a role for the D3 receptor in
schizophrenia and drug addiction. The D3 receptor is expressed in brain regions controlling …
schizophrenia and drug addiction. The D3 receptor is expressed in brain regions controlling …