The advantages of the model organism Drosophila melanogaster, including low genetic
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …

Getting a good night's sleep is on everyone's to-do list. So is, no doubt, staying awake during
late afternoon seminars. Our internal clocks control these and many more workings of the …

Human osteoarthritis is a progressive disease of the joints characterized by degradation of
articular cartilage. Although disease initiation may be multifactorial, the cartilage destruction …

Familial advanced sleep phase syndrome (FASPS) is a human behavioural phenotype
characterized by early sleep times and early-morning awakening. It was the first human …

The mammalian circadian regulatory proteins PER1 and PER2 undergo a daily cycle of
accumulation followed by phosphorylation and degradation. Although phosphorylation …

A genetic screen for mutants that alter circadian rhythms in Drosophila identified the first
clock gene—the period (per) gene. The per gene is a central player within a transcriptional …

Circadian rhythms influence most of our life activities, notably getting up and going to sleep
every day. The new edition of this book delves into the mechanisms surrounding how these …

The human body persists in its rhythm as per its initial time zone, and transition always occur
according to solar movements around the earth over 24 h. While traveling across different …

Daily rhythms in behavior, physiology and metabolism are controlled by endogenous
circadian clocks. At the heart of these clocks is a circadian oscillator that keeps circadian …

CRYPTOCHROME (CRY) is the primary circadian photoreceptor in Drosophila. We show
that CRY binding to TIMELESS (TIM) is light-dependent in flies and irreversibly commits TIM …