Vitamin A update: forms, sources, kinetics, detection, function, deficiency, therapeutic use and toxicity
A Carazo, K Macáková, K Matoušová, LK Krčmová… - Nutrients, 2021 - mdpi.com
Vitamin A is a group of vital micronutrients widely present in the human diet. Animal-based
products are a rich source of the retinyl ester form of the vitamin, while vegetables and fruits …
products are a rich source of the retinyl ester form of the vitamin, while vegetables and fruits …
[HTML][HTML] Nuclear receptors, RXR, and the big bang
Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid
hormone and their structural and functional analysis revealed an evolutionarily conserved …
hormone and their structural and functional analysis revealed an evolutionarily conserved …
Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders
WS Blaner - Pharmacology & therapeutics, 2019 - Elsevier
Much evidence has accumulated in the literature over the last fifteen years that indicates
vitamin A has a role in metabolic disease prevention and causation. This literature proposes …
vitamin A has a role in metabolic disease prevention and causation. This literature proposes …
Biological functions of RBP4 and its relevance for human diseases
JS Steinhoff, A Lass, M Schupp - Frontiers in Physiology, 2021 - frontiersin.org
Retinol binding protein 4 (RBP4) is a member of the lipocalin family and the major transport
protein of the hydrophobic molecule retinol, also known as vitamin A, in the circulation …
protein of the hydrophobic molecule retinol, also known as vitamin A, in the circulation …
Retinoic acid receptors at 35 years
M Petkovich, P Chambon - Journal of Molecular …, 2022 - jme.bioscientifica.com
For almost a century, vitamin A has been known as a nutrient critical for normal
development, differentiation, and homeostasis; accordingly, there has been much interest in …
development, differentiation, and homeostasis; accordingly, there has been much interest in …
Retinoic acid receptors: from molecular mechanisms to cancer therapy
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
Isolation and structure of a brain constituent that binds to the cannabinoid receptor
WA Devane, L Hanuš, A Breuer, RG Pertwee… - Science, 1992 - science.org
Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in
a screen for endogenous ligands for the cannabinoid receptor. The structure of this …
a screen for endogenous ligands for the cannabinoid receptor. The structure of this …
Physiological and molecular basis of thyroid hormone action
PM Yen - Physiological reviews, 2001 - journals.physiology.org
Thyroid hormones (THs) play critical roles in the differentiation, growth, metabolism, and
physiological function of virtually all tissues. TH binds to receptors that are ligand …
physiological function of virtually all tissues. TH binds to receptors that are ligand …
Mechanistic aspects of carotenoid health benefits–where are we now?
Dietary intake and tissue levels of carotenoids have been associated with a reduced risk of
several chronic diseases, including cardiovascular diseases, type 2 diabetes, obesity, brain …
several chronic diseases, including cardiovascular diseases, type 2 diabetes, obesity, brain …
The RXR heterodimers and orphan receptors
The nuclear receptor superfamily is comprised of over 150 different proteins that have
evolved to mediate a complex array of extracellular signals into transcriptional responses …
evolved to mediate a complex array of extracellular signals into transcriptional responses …