Vitamin A update: forms, sources, kinetics, detection, function, deficiency, therapeutic use and toxicity

A Carazo, K Macáková, K Matoušová, LK Krčmová… - Nutrients, 2021 - mdpi.com
Vitamin A is a group of vital micronutrients widely present in the human diet. Animal-based
products are a rich source of the retinyl ester form of the vitamin, while vegetables and fruits …

[HTML][HTML] Nuclear receptors, RXR, and the big bang

RM Evans, DJ Mangelsdorf - Cell, 2014 - cell.com
Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid
hormone and their structural and functional analysis revealed an evolutionarily conserved …

Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders

WS Blaner - Pharmacology & therapeutics, 2019 - Elsevier
Much evidence has accumulated in the literature over the last fifteen years that indicates
vitamin A has a role in metabolic disease prevention and causation. This literature proposes …

Biological functions of RBP4 and its relevance for human diseases

JS Steinhoff, A Lass, M Schupp - Frontiers in Physiology, 2021 - frontiersin.org
Retinol binding protein 4 (RBP4) is a member of the lipocalin family and the major transport
protein of the hydrophobic molecule retinol, also known as vitamin A, in the circulation …

Retinoic acid receptors at 35 years

M Petkovich, P Chambon - Journal of Molecular …, 2022 - jme.bioscientifica.com
For almost a century, vitamin A has been known as a nutrient critical for normal
development, differentiation, and homeostasis; accordingly, there has been much interest in …

Retinoic acid receptors: from molecular mechanisms to cancer therapy

A Di Masi, L Leboffe, E De Marinis, F Pagano… - Molecular aspects of …, 2015 - Elsevier
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Isolation and structure of a brain constituent that binds to the cannabinoid receptor

WA Devane, L Hanuš, A Breuer, RG Pertwee… - Science, 1992 - science.org
Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in
a screen for endogenous ligands for the cannabinoid receptor. The structure of this …

Physiological and molecular basis of thyroid hormone action

PM Yen - Physiological reviews, 2001 - journals.physiology.org
Thyroid hormones (THs) play critical roles in the differentiation, growth, metabolism, and
physiological function of virtually all tissues. TH binds to receptors that are ligand …

Mechanistic aspects of carotenoid health benefits–where are we now?

T Bohn, ML Bonet, P Borel, J Keijer… - Nutrition Research …, 2021 - cambridge.org
Dietary intake and tissue levels of carotenoids have been associated with a reduced risk of
several chronic diseases, including cardiovascular diseases, type 2 diabetes, obesity, brain …

The RXR heterodimers and orphan receptors

DJ Mangelsdorf, RM Evans - Cell, 1995 - Elsevier
The nuclear receptor superfamily is comprised of over 150 different proteins that have
evolved to mediate a complex array of extracellular signals into transcriptional responses …