Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Gap junctions consist of arrays of intercellular channels that enable adjacent cells to
communicate both electrically and metabolically. Gap junctions have a wide diversity of …

Evaluation of the human genome suggests that all members of the connexin family of gap-
junction proteins have now been successfully identified. This large and diverse family of …

Mutations in the lamin A/C gene (LMNA) cause dilated cardiomyopathy associated with
increased activity of ERK1/2 in the heart. We recently showed that ERK1/2 phosphorylates …

Recombinant proteins containing tetracysteine tags can be successively labeled in living
cells with different colors of biarsenical fluorophores so that older and younger protein …

Gap junctions consist of intercellular channels that connect the cytoplasm of adjacent cells
directly and allow the exchange of small molecules. These channels are unique in that they …

Gap junctions, composed of proteins from the connexin gene family, are highly dynamic
structures that are regulated by kinase-mediated signaling pathways and interactions with …

Connexin 43 (Cx43) nonjunctional or “unapposed” hemichannels can open under
physiological or pathological conditions. We characterize hemichannels comprised of Cx43 …

Gap junctions are intercellular channels that connect the cytoplasms of adjacent cells. For
gap junctions to properly control organ formation and electrical synchronization in the heart …

Connexin 43 (Cx43) is a gap junction (GJ) protein widely expressed in mammalian tissues
that mediates cell-to-cell coupling. Intercellular channels comprising GJ aggregates form …